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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Cerovecki, T; Bojanic, I; Brcic, L; Radic, B; Vukoja, I; Seiwerth, S; Sikiric, P.
Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat.
J Orthop Res. 2010; 28(9): 1155-1161.
Doi: 10.1002/jor.21107
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- Abstract:
- We improved medial collateral ligament (MCL) healing throughout 90 days after surgical transection. We introduced intraperitoneal, per-oral (in drinking water) and topical (thin cream layer) peptide therapy always given alone, without a carrier. Previously, as an effective peptide therapy, stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, an anti-ulcer peptide effective in inflammatory bowel disease therapy (PL 14736)) particularly improved healing of transected tendon and muscle and wound healing effect including the expression of the early growth response 1 (egr-1) gene. After MCL transection BPC 157 was effective in rats when given once daily intraperitoneally (10 microg or 10 ng/kg) or locally as a thin layer (1.0 microg dissolved in distilled water/g commercial neutral cream) at the site of injury, first application 30 min after surgery and the final application 24 h before sacrifice. Likewise, BPC 157 was effective given per-orally (0.16 microg/ml in the drinking water (12 ml/day/rat)) until sacrifice. Commonly, BPC 157 microg-ng-rats exhibited consistent functional, biomechanical, macroscopic and histological healing improvements. Thus, we suggest BPC 157 improved healing of acute ligament injuries in further ligament therapy. (c) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Animals -
- Collagen Type I - metabolism
- Collagen Type III - metabolism
- Contracture - prevention & control
- Disease Models, Animal -
- Male -
- Medial Collateral Ligament, Knee - drug effects Medial Collateral Ligament, Knee - injuries Medial Collateral Ligament, Knee - physiology
- Motor Activity - drug effects
- Neutrophils - physiology
- Peptide Fragments - pharmacology
- Proteins - pharmacology
- Rats -
- Rats, Wistar -
- Recovery of Function - drug effects
- Wound Healing - drug effects
- Find related publications in this database (Keywords)
- pentadecapeptide BPC 157
- acute ligament injury
- rat