Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dejaco, C; Oppl, B; Monach, P; Cuthbertson, D; Carette, S; Hoffman, G; Khalidi, N; Koening, C; Langford, C; McKinnon-Maksimowicz, K; Seo, P; Specks, U; Ytterberg, S; Merkel, PA; Zwerina, J.
Serum biomarkers in patients with relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss).
PLoS One. 2015; 10(3):e0121737-e0121737
Doi: 10.1371/journal.pone.0121737
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Dejaco Christian
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- Abstract:
- Previous studies suggest a role for eotaxin-3, TARC/CCL17 and IgG4 in newly-diagnosed patients with eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss) with highly active disease. The role of these biomarkers in relapsing disease is unclear. Serum levels of TARC/CCL17, eotaxin-3, IgG4, and IgG4/IgG ratio were determined in serum samples from a longitudinal cohort of patients with EGPA (105 visits of 25 patients). Epidemiological, clinical and laboratory data were available for all visits. At the first visit, 80% of patients were using glucocorticoids and 68% additional immunosuppressive drugs. Disease flares were seen at 18 visits. The median BVAS and BVAS/WG scores at time of relapse were 4 and 2, respectively. None of the biomarkers tested were useful to discriminate between active disease and remission. Patients treated with prednisone had lower eotaxin-3 and eosinophil levels compared to patients not taking glucocorticoids irrespective of disease activity. Use of immunosuppressive agents was not associated with biomarker levels. Serum levels of TARC/CCL17, eotaxin-3, IgG4, and IgG4/IgG ratio do not clearly differentiate active and inactive disease in established EGPA. Defining biomarkers in EGPA remains a challenge especially during times of glucocorticoid use.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biomarkers -
- Chemokine CCL17 - blood
- Chemokines, CC - blood
- Churg-Strauss Syndrome - blood
- Eosinophils -
- Female -
- Humans -
- Immunoglobulin G - blood
- Immunosuppressive Agents - therapeutic use
- Male -
- Middle Aged -
- Recurrence -