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SHR Neuro Cancer Cardio Lipid Metab Microb
Kirsch, AH; Kirsch, A; Artinger, K; Schabhüttl, C; Goessler, W; Klymiuk, I; Gülly, C; Fritz, GA; Frank, S; Wimmer, R; Brodmann, M; Anders, HJ; Pramstaller, PP; Rosenkranz, AR; Eller, K; Eller, P.
Heterogeneous susceptibility for uraemic media calcification and concomitant inflammation within the arterial tree.
Nephrol Dial Transplant. 2015; 30(12):1995-2005
Doi: 10.1093/ndt/gfv265
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- Leading authors Med Uni Graz
- Eller Philipp
- Kirsch Alexander
- Co-authors Med Uni Graz
- Artinger Katharina
- Brodmann Marianne
- Eller Kathrin
- Frank Sasa
- Fritz Gerald
- Gülly Christian
- Kirsch Andrijana
- Klymiuk Ingeborg
- Rosenkranz Alexander
- Schabhüttl Corinna
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- Abstract:
- End-stage renal disease (ESRD) is strongly associated with arterial calcification of the tunica media, decreased vascular compliance and sudden cardiac death. Here, we analysed the distribution pattern of uraemic media calcification and concomitant inflammation in mice and men. Uraemia was induced in DBA/2 mice with high-phosphate diet. Subsequently, we analysed arterial medial calcification using histology, mass spectrometry, and wire myography. Gene expression was quantified using a whole transcriptome array and quantitative PCR. In a cohort of 36 consecutive patients with CKD stage 4-5, we measured the calcium score of the coronary arteries, the ascending thoracic aorta and the infrarenal abdominal aorta using computed tomography scans. Uraemic DBA/2 mice showed only minor calcifications in thoracic aortas, whereas there was overt media calcification in abdominal aortas. The transcriptional profile and immunohistochemistry revealed induction of Vcam1 expression by vascular smooth muscle cells in uraemic abdominal aortas. Macrophages infiltrated the tunica media of the abdominal aorta. Anti-inflammatory treatment did not improve uraemic media calcification in our animal model. Arterial calcifications in ESRD patients showed a similar distribution pattern in computed tomography scans, with higher calcium scores of the abdominal aorta when compared with the thoracic aorta. Taken together, there was a similar heterogeneous pattern of calcification in both mice and humans, where the abdominal aorta was more prone to media calcification when compared with the thoracic aorta. In uraemia, smooth muscle cells of the abdominal aorta showed a phenotypic switch to an inflammatory and osteoblastic phenotype. © The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Aorta, Thoracic - metabolism
- Calcium - metabolism
- Disease Models, Animal -
- Disease Susceptibility -
- Female -
- Humans -
- Inflammation - etiology
- Inflammation - metabolism
- Kidney Failure, Chronic - complications
- Kidney Failure, Chronic - metabolism
- Kidney Failure, Chronic - pathology
- Male -
- Mice -
- Mice, Inbred DBA -
- Middle Aged -
- Muscle, Smooth, Vascular - immunology
- Muscle, Smooth, Vascular - metabolism
- Muscle, Smooth, Vascular - pathology
- Retrospective Studies -
- Tomography, X-Ray Computed -
- Uremia - physiopathology
- Vascular Calcification - physiopathology
- Find related publications in this database (Keywords)
- atherosclerosis
- coronary calcification
- ESRD
- inflammation
- vascular calcification