Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lindenmann, J; Fink-Neuboeck, N; Schilcher, G; Smolle-Juettner, FM.
Severe methaemoglobinaemia treated with adjunctive hyperbaric oxygenation.
Diving Hyperb Med. 2015; 45(2):132-134
(- Case Report)
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Lindenmann Jörg
- Co-Autor*innen der Med Uni Graz
- Fink-Neuböck Nicole
- Schilcher Gernot
- Smolle-Juettner Freyja-Maria
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- Methaemoglobinaemia results from exposure to oxidizing substances such as nitrates or nitrites. Iron within haemoglobin is oxidized from the ferrous to the ferric state, which blocks the transport of oxygen and carbon dioxide, with subsequent inhibition of the respiratory chain. We describe the case of a 23-year-old male suffering from severe methaemoglobinaemia of 68% after consumption of nitrites ('poppers') in association with considerable ethanol consumption. Toluidine-blue was administered as first-line antidotal therapy immediately followed by hyperbaric oxygenation (HBOT). HBOT resulted in enhanced reduction of methaemoglobin, and rapid tissue re-oxygenation by the oxygen dissolved in plasma was provided, independent of the degree of methaemoglobinaemia. The patient recovered uneventfully and was discharged three days later. This case illustrates the potential of supportive HBOT as a time-saving therapeutic tool in this unusual situation, enabling a quick and sustained reduction in methaemoglobinaemia.
- Find related publications in this database (using NLM MeSH Indexing)
- Alcohol Drinking - adverse effects
- Humans -
- Hyperbaric Oxygenation - methods
- Male -
- Methemoglobinemia - blood
- Methemoglobinemia - chemically induced
- Methemoglobinemia - therapy
- Nitrites - poisoning
- Substance-Related Disorders - complications
- Young Adult -
- Find related publications in this database (Keywords)
- Hyperbaric oxygen therapy
- drugs
- toxicity
- hypoxia
- neuroprotection
- case reports