Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gary, T; Prüller, F; Raggam, R; Mahla, E; Eller, P; Hafner, F; Brodmann, M.
High Residual Collagen-Induced Platelet Reactivity Predicts Development of Restenosis in the Superficial Femoral Artery After Percutaneous Transluminal Angioplasty in Claudicant Patients.
Cardiovasc Intervent Radiol. 2016; 39(2):190-194
Doi: 10.1007/s00270-015-1172-6
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- Führende Autor*innen der Med Uni Graz
- Gary Thomas
- Co-Autor*innen der Med Uni Graz
- Brodmann Marianne
- Eller Philipp
- Hafner Franz
- Mahla Elisabeth
- Prüller Florian
- Raggam Reinhard Bernd
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- Abstract:
- Although platelet reactivity is routinely inhibited with aspirin after percutaneous angioplasty (PTA) in peripheral arteries, the restenosis rate in the superficial femoral artery (SFA) is high. Interaction of activated platelets and the endothelium in the region of intervention could be one reason for this as collagen in the subendothelium activates platelets. A prospective study evaluating on-site platelet reactivity during PTA and its influence on the development of restenosis with a total of 30 patients scheduled for PTA of the SFA. Arterial blood was taken from the PTA site after SFA; platelet function was evaluated with light transmission aggregometry. After 3, 6, 12, and 24 months, duplex sonography was performed and the restenosis rate evaluated. Eight out of 30 patients developed a hemodynamically relevant restenosis (>50 % lumen narrowing) in the PTA region during the 24-month follow-up period. High residual collagen-induced platelet reactivity defined as AUC >30 was a significant predictor for the development of restenosis [adjusted odds ratio 11.8 (9.4, 14.2); P = .04]. High residual collagen-induced platelet reactivity at the interventional site predicts development of restenosis after PTA of the SFA. Platelet function testing may be useful for identifying patients at risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Angiography -
- Angioplasty - methods
- Aspirin - administration & dosage
- Blood Platelets - physiology
- Collagen - physiology
- Female -
- Femoral Artery -
- Hemodynamics -
- Humans -
- Intermittent Claudication - diagnostic imaging
- Intermittent Claudication - physiopathology
- Intermittent Claudication - therapy
- Male -
- Middle Aged -
- Platelet Aggregation Inhibitors - administration & dosage
- Predictive Value of Tests -
- Prospective Studies -
- Recurrence -
- Risk Factors -
- Ultrasonography -