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SHR Neuro Cancer Cardio Lipid Metab Microb

Resch, A; Harbaum, L; Pollheimer, MJ; Kornprat, P; Lindtner, RA; Langner, C.
Grading lymph node metastasis: a feasible approach for prognostication of patients with stage III colorectal cancer.
J Clin Pathol. 2015; 68(9):742-745 Doi: 10.1136/jclinpath-2014-202772
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Leading authors Med Uni Graz: Langner Cord; Resch Annika
Co-authors Med Uni Graz: Kornprat Peter; Pollheimer Marion
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Abstract:: This study aimed to assess the clinicopathological significance of tumour differentiation of metastatic lymph node tissue in patients with American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) stage III colorectal cancer. In a cohort of 145 patients, lymph node grades were G1 in 77 (53.1%), G2 in 41 (28.3%) and G3 in 27 (18.6%) cases, respectively. Despite differences in 77 (53.1%) cases, primary tumour and lymph node grade correlated significantly (Somer's D=0.639; p<0.001). Lymph node grade was significantly associated with N classification (p=0.009), tumour size (p=0.024) and lymphovascular invasion (p=0.004). Patients with lymph node grade G1 had better progression-free survival (p=0.031) and cancer-specific survival (p=0.008). Multivariable analysis identified lymph node grade as independent predictor of cancer-specific survival in this cohort. In conclusion, lymph node grade emerged as a promising novel prognostic variable for patients with AJCC/UICC stage III disease. Additional studies are warranted to validate this new finding. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Find related publications in this database (using NLM MeSH Indexing): Adenocarcinoma - mortality Adenocarcinoma - pathology; Adult -; Aged -; Aged, 80 and over -; Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology; Disease-Free Survival -; Female -; Humans -; Lymphatic Metastasis -; Male -; Middle Aged -; Neoplasm Grading - methods; Neoplasm Staging -; Prognosis -