Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Resch, A; Harbaum, L; Pollheimer, MJ; Kornprat, P; Lindtner, RA; Langner, C.
Grading lymph node metastasis: a feasible approach for prognostication of patients with stage III colorectal cancer.
J Clin Pathol. 2015; 68(9):742-745
Doi: 10.1136/jclinpath-2014-202772
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Resch Annika
- Co-Autor*innen der Med Uni Graz
- Kornprat Peter
- Pollheimer Marion
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- Abstract:
- This study aimed to assess the clinicopathological significance of tumour differentiation of metastatic lymph node tissue in patients with American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) stage III colorectal cancer. In a cohort of 145 patients, lymph node grades were G1 in 77 (53.1%), G2 in 41 (28.3%) and G3 in 27 (18.6%) cases, respectively. Despite differences in 77 (53.1%) cases, primary tumour and lymph node grade correlated significantly (Somer's D=0.639; p<0.001). Lymph node grade was significantly associated with N classification (p=0.009), tumour size (p=0.024) and lymphovascular invasion (p=0.004). Patients with lymph node grade G1 had better progression-free survival (p=0.031) and cancer-specific survival (p=0.008). Multivariable analysis identified lymph node grade as independent predictor of cancer-specific survival in this cohort. In conclusion, lymph node grade emerged as a promising novel prognostic variable for patients with AJCC/UICC stage III disease. Additional studies are warranted to validate this new finding. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - mortality Adenocarcinoma - pathology
- Adult -
- Aged -
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- Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology
- Disease-Free Survival -
- Female -
- Humans -
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Neoplasm Grading - methods
- Neoplasm Staging -
- Prognosis -