Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Graupp, M; Bachna-Rotter, S; Gerstenberger, C; Friedrich, G; Fröhlich-Sorger, E; Kiesler, K; Gugatschka, M.
The unsolved chapter of vocal fold scars and how tissue engineering could help us solve the problem.
Eur Arch Otorhinolaryngol. 2016; 273(9):2279-2284
Doi: 10.1007/s00405-015-3668-8
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- Führende Autor*innen der Med Uni Graz
- Koiner-Graupp Matthias
- Co-Autor*innen der Med Uni Graz
- Bachna-Rotter Sophie
- Friedrich Gerhard
- Fröhlich-Sorger Elke Verena
- Gerstenberger Claus
- Gugatschka Markus
- Kiesler Karl
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- Abstract:
- Vocal fold scarring is a relatively small field in scar research with prerequisites found nowhere else. The deterioration of the delicate tri-layered micro-structure of the epithelium of the vocal folds leads to impaired vibration characteristics resulting in a permanent hoarse and breathy voice. Tissue engineering approaches could help to restore the pre-injury status. Despite a considerable progress in this field during the last years, routine clinical applications are not available so far. One reason might be that vocal fold fibroblasts, as the responsible cell type for fibrogenesis, have very particular properties that are only poorly characterized. Moreover, in vivo trials are costly and time consuming and a representative in vitro model does not exist so far. These particular circumstances lead to innovative in vitro strategies and concepts such as macro-molecular crowding that can also be applied in adjacent fields.
- Find related publications in this database (using NLM MeSH Indexing)
- Cicatrix - etiology
- Cicatrix - therapy
- Fibroblasts -
- Hoarseness - etiology
- Hoarseness - therapy
- Humans -
- Postoperative Complications - etiology
- Postoperative Complications - therapy
- Tissue Engineering -
- Vocal Cords - surgery
- Find related publications in this database (Keywords)
- Vocal fold scar
- Laryngeal tissue engineering
- Macro-molecular crowding