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SHR Neuro Cancer Cardio Lipid Metab Microb
Resch, B; Resch, E; Maurer-Fellbaum, U; Pichler-Stachl, E; Riccabona, M; Hofer, N; Urlesberger, B.
The whole spectrum of cystic periventricular leukomalacia of the preterm infant: results from a large consecutive case series.
Childs Nerv Syst. 2015; 31(9):1527-1532
Doi: 10.1007/s00381-015-2786-3
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Resch Bernhard
- Co-authors Med Uni Graz
- Hofer Nora
- Maurer-Fellbaum Ute
- Pichler-Stachl Elisabeth
- Resch-Poteralski Elisabeth
- Riccabona Michael
- Urlesberger Berndt
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- Abstract:
- The purpose of this study is to describe features of cystic periventricular leukomalacia (PVL) in a large consecutive cohort study including long-term neurodevelopmental follow-up. We performed a retrospective single-centre cohort study including all preterm infants ≤35 weeks of gestational age with PVL diagnosed by ultrasound scans (US) from a tertiary care university hospital between 1988 and 2012. The majority of 160 consecutively diagnosed cases had a gestational age between 28 and 32 weeks (60.6%), and male sex was predominant (60.6%). The most common associated clinical findings included respiratory distress syndrome, preterm premature rupture of the membranes, and chorioamnionitis (57.5, 49.4, and 39.4%, respectively). Infants presented with apnoeas in 66.3 and neonatal seizures in 23.1%. Any kind of respiratory support was present in 75.0%. Associated low-grade intraventricular haemorrhage was evident in 33.1, high-grade haemorrhage in 9.4%. Cysts were located on both hemispheres in 75% and PVL grades 3 and 4 were predominant (75.6%). Neurodevelopmental follow-up of 146 cases at a median age of 72 months revealed normal development in 11.0, mental retardation in 50.0, and cerebral palsy in 83.6%. Visual impairment was diagnosed in 21.9% and hearing impairment in one case. A quarter of cases (27.4%) developed seizure disorders. Outcome data were significantly better in unilateral compared to bilateral PVL. Long-term neurodevelopmental outcome of bilateral PVL always was adverse and different from unilateral PVL. The latter might be negatively influenced by associated intra- and periventricular haemorrhages.
- Find related publications in this database (using NLM MeSH Indexing)
- Cohort Studies -
- Developmental Disabilities - etiology
- Female -
- Gestational Age -
- Humans -
- Infant -
- Infant, Newborn -
- Infant, Premature -
- Leukomalacia, Periventricular - complications
- Leukomalacia, Periventricular - diagnosis
- Leukomalacia, Periventricular - therapy
- Male -
- Maternal Age -
- Find related publications in this database (Keywords)
- Neurodevelopmental outcome
- Periventricular leukomalacia
- Preterm infant
- Risk factors
- Ultrasound scans