Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Belaj, K; Pichler, M; Hackl, G; Rief, P; Eller, P; Hafner, F; Brodmann, M; Gary, T.
Association of the Derived Neutrophil-Lymphocyte Ratio With Critical Limb Ischemia.
Angiology. 2016; 67(4):350-354
Doi: 10.1177/0003319715590701
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Belaj Klara
- Gary Thomas
- Co-Autor*innen der Med Uni Graz
- Brodmann Marianne
- Eller Philipp
- Hackl Gerald
- Hafner Franz
- Pichler Martin
- Rief Peter
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- Abstract:
- Neutrophil and leukocyte counts are laboratory parameters that reflect the systemic inflammatory response in patients with atherosclerotic diseases. Based on the means of these parameters, the derived neutrophil-lymphocyte ratio (dNLR) can be calculated. We investigated a possible association of critical limb ischemia (CLI) and the dNLR in patients with peripheral arterial disease (PAD). We performed a retrospective data analysis including 1995 patients with PAD treated at our department in the years 2005 to 2010. The cohort was divided into tertiles according to dNLR. Higher dNLR values were associated with an increased CLI rate. In the tertile with lowest dNLR, the CLI rate was 20.4%, in the second tertile the CLI rate was 26.1%, and in the third tertile the CLI rate was 36.1%. Statistical significance was shown using a Jonckheere-Terpstra test (P < .001). A high dNLR is associated with an increased rate of CLI in patients with PAD. This might be a useful parameter to highlight patients at increased risk of CLI. © The Author(s) 2015.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Extremities -
- Female -
- Humans -
- Ischemia - etiology
- Lymphocyte Count - methods
- Lymphocytes - cytology
- Male -
- Middle Aged -
- Neutrophils - cytology
- Peripheral Arterial Disease - complications
- Peripheral Arterial Disease - diagnosis
- Retrospective Studies -
- Risk Assessment -
- Risk Factors -
- Find related publications in this database (Keywords)
- critical limb ischemia
- derived neutrophil-lymphocyte ratio
- peripheral arterial disease