Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Obermayer-Pietsch, B; Trummer, C; Schwetz, V; Schweighofer, N; Pieber, T.
Genetics of insulin resistance in polycystic ovary syndrome.
Curr Opin Clin Nutr Metab Care. 2015; 18(4):401-406
Doi: 10.1097/MCO.0000000000000190
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
- Co-Autor*innen der Med Uni Graz
- Schweighofer Natascha
- Theiler-Schwetz Verena
- Trummer Christian
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- Abstract:
- Polycystic ovary syndrome (PCOS) is a very common endocrine disease in women all over the world. A variety of symptoms such as hirsutism and hyperandrogenism, irregular menstrual cycles and anovulatory infertility together with metabolic dysfunction, insulin resistance, and type 2 diabetes mellitus in lean and obese individuals and the development of consecutive diseases are key problems in this heterogeneous syndrome. Disease-modifying and potentially disease-causing candidate genes are described. A number of genetic associations have been investigated, whereby genes related to normal-weight insulin resistance and chronic inflammation are of central interest for PCOS pathomechanisms. New insights in the pharmacogenetics of PCOS might help to individualize therapeutic options. Enormous progress has been made in the genetics of insulin resistance in PCOS. However, because of the individual heterogeneity of PCOS and the lack of evident functional studies, the syndrome is only partly understood to date. Large studies on selected phenotypes and therapy aspects are ongoing.
- Find related publications in this database (using NLM MeSH Indexing)
- Diabetes Mellitus, Type 2 - genetics
- Energy Metabolism -
- Female -
- Humans -
- Infertility, Female - genetics
- Insulin Resistance - genetics
- Pharmacogenetics -
- Polycystic Ovary Syndrome - genetics
- Find related publications in this database (Keywords)
- androgens
- genetics
- insulin resistance
- polycystic ovary syndrome
- type 2 diabetes mellitus