Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Krones, E; Wagner, M; Eller, K; Rosenkranz, AR; Trauner, M; Fickert, P.
Bile acid-induced cholemic nephropathy.
Dig Dis. 2015; 33(3):367-375
Doi: 10.1159/000371689
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Fickert Peter
- Tatscher Elisabeth
- Co-Autor*innen der Med Uni Graz
- Eller Kathrin
- Rosenkranz Alexander
- Trauner Michael
- Wagner Martin
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- Abstract:
- Kidney injury in deeply jaundiced patients became known as cholemic nephropathy. This umbrella term covers impaired renal function in cholestatic patients with characteristic histomorphological changes including intratubular cast formation and tubular epithelial cell injury. Cholemic nephropathy represents a widely underestimated but important cause of kidney dysfunction in patients with cholestasis and advanced liver disease. However, the nomenclature is inconsistent since there are numerous synonyms used; the underlying mechanisms of cholemic nephropathy are not entirely clear, and widely accepted diagnostic criteria are still missing. Consequently, the current article aims to summarize the present knowledge on the clinical and morphological characteristics, available preclinical models, derived potential pathomechanisms, and future diagnostic and therapeutic strategies in cholemic nephropathy. Furthermore, we provide a potential research agenda for this evolving field. 2015 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Kidney Injury - etiology
- Bile Acids and Salts - metabolism
- Cholestasis - complications
- Cholestasis - metabolism
- Hepatorenal Syndrome - etiology
- Humans -
- Jaundice, Obstructive - complications
- Jaundice, Obstructive - metabolism
- Kidney Diseases - etiology
- Kidney Diseases - pathology
- Terminology as Topic -
- Find related publications in this database (Keywords)
- Acute kidney injury
- Cholemic nephropathy
- Hepatorenal syndrome