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Selected Publication:
Fürnsinn, C; Leuvenink, H; Roden, M; Nowotny, P; Schneider, B; Rohac, M; Pieber, T; Clodi, M; Waldhäusl, W.
Islet amyloid polypeptide inhibits insulin secretion in conscious rats.
Am J Physiol. 1994; 267(2 Pt 1):E300-E305
Doi: 10.1152/ajpendo.1994.267.2.E300
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- Pieber Thomas
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- Abstract:
- To investigate the effect of islet amyloid polypeptide (IAPP, amylin) exposure on insulin secretion in vivo, the plasma glucose level of conscious rats was clamped at 11.1 mmol/l (hyperglycemic clamp) during the last 2 h of a 24-h infusion study. Group parameters were A, 24-h saline; B and C, 22-h saline followed by 2-h IAPP (B, 8.5 pmol/min; C, 85 pmol/min), and D, 24-h IAPP (85 pmol/min). Induced hyperglycemia increased plasma insulin concentration by 426 +/- 34 pmol/l in control rats (group A). This effect on plasma insulin was reduced by 31% and 53% during short-term IAPP infusion (group B, 8.5 pmol/min, 294 +/- 41 pmol/l; C, 85 pmol/min, 202 +/- 25 pmol/l; short-term effect, P < 0.0001), whereas insulin levels tended to increase after 24 h of continuous IAPP exposure (group D, 682 +/- 120 pmol/l; P < 0.05 vs. group A). Glucose infusion rate required to maintain constant hyperglycemia fell dose dependently during short-term but not during long-term IAPP infusion (mumol.kg-1.min-1: group A, 203 +/- 11; B, 154 +/- 7; C, 119 +/- 7; D, 212 +/- 9; short-term effect, P < 0.0001). In parallel, muscle glycogen content was dose dependently reduced by short-term IAPP exposure. We conclude that IAPP inhibits glucose-stimulated insulin secretion and decreases muscle glycogen storage in conscious rats in vivo.
- Find related publications in this database (using NLM MeSH Indexing)
- Amyloid - pharmacology
- Animals - pharmacology
- Glucose - pharmacology
- Glucose Clamp Technique - pharmacology
- Glycogen - metabolism
- Insulin - blood
- Insulin Antagonists - pharmacology
- Liver - metabolism
- Male - metabolism
- Muscles - metabolism
- Myocardium - metabolism
- Rats - metabolism
- Rats, Sprague-Dawley - metabolism
- Time Factors - metabolism
- Find related publications in this database (Keywords)
- Islet Amyloid Polypeptide
- Amylin
- Insulin Secretion
- Muscle Glycogen
- Insulin Resistance