Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pircher, A; Gamerith, G; Amann, A; Reinold, S; Popper, H; Gächter, A; Pall, G; Wöll, E; Jamnig, H; Gastl, G; Wolf, AM; Hilbe, W; Wolf, D.
Neoadjuvant chemo-immunotherapy modifies CD4(+)CD25(+) regulatory T cells (Treg) in non-small cell lung cancer (NSCLC) patients.
Lung Cancer. 2014; 85(1): 81-87.
Doi: 10.1016/j.lungcan.2014.04.001
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Popper Helmuth
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- Abstract:
- Regulatory T cells (Treg) are critical for cancer immune evasion; whereas natural killer (NK) cells are central for effective anti-tumor immunity including antibody-induced cellular cytotoxicity (ADCC). The predictive role of Treg levels for clinical response to chemo-immunotherapy in non-small cell lung cancer (NSCLC) as well as therapy-induced Treg changes remain to be defined. The impact of Treg on NK-mediated cetuximab-dependent cellular cytoxicity was tested in vitro. Frequency and functional activity of Treg was analyzed in 31 NSCLC stage IB-IIIA patients treated by neoadjuvant Cetuximab/Docetaxel/Cisplatin prior to surgery. Data were correlated with clinical outcome variables and Treg tumor infiltration. Treg potently inhibit NK-mediated and cetuximab-induced ADCC in vitro. In addition, a significant correlation between Treg reduction and clinical response was seen. However, the grade of tumor infiltrating Treg in resected tumors did not correlate with peripheral Treg levels. Moreover, Treg levels at diagnosis did not predict clinical response to chemo-immunotherapy. The drop of Treg levels during neoadjuvant chemo-immunotherapy in NSCLC patients significantly correlates with clinical response. However, Treg at diagnosis are not linked to inferior clinical response to chemo-immunotherapy in NSCLC in vivo even though Treg efficiently inhibit ADCC in vitro. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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- Antibodies, Monoclonal, Humanized - administration & dosage
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- Find related publications in this database (Keywords)
- Regulatory T cells (Treg)
- Non-small cell lung cancer (NSCLC)
- Neoadjuvant therapy
- Cetuximab
- Antibody-induced cellular cytotoxicity (ADCC)
- Chemo-immunotherapy