Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hutterer, GC; Krieger, D; Mrsic, E; Pohlmann, K; Bezan, A; Stojakovic, T; Pummer, K; Zigeuner, R; Pichler, M.
Preoperative Leucocytosis, Thrombocytosis and Anemia as Potential Prognostic Factors in Non-metastatic Renal Cell Carcinoma.
Anticancer Res. 2015; 35(6):3463-3469
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Hutterer Georg
- Co-Autor*innen der Med Uni Graz
- Pichler Martin
- Pummer Karl
- Stojakovic Tatjana
- Terbuch Angelika
- Zigeuner Richard
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- Abstract:
- To validate the potential prognostic significance of preoperatively assessed inflammatory parameters leucocytosis, thrombocytosis and anemia in patients with non-metastatic renal cell carcinoma (RCC). We retrospectively evaluated a cohort comprising 736 consecutive patients with non-metastatic RCC, operated on between 2004 and 2012 with curative radical or partial nephrectomy at a single tertiary academic centre. Laboratory parameters were assessed within one week before surgical intervention. Patients were categorized using laboratory parameter cut-off values according to receiver operating characteristics (ROC) analyses. Cancer-specific survival (CSS) was assessed using the Kaplan-Meier method. To evaluate the potential prognostic significance of the preoperative laboratory parameters, multivariate Cox regression models were applied. Multivariable analysis identified preoperative thrombocytosis (≥285,000/μl) as an independent prognostic factor for CSS (Hazard ratio=2.28, 95% confidence interval=1.24-4.20, p=0.008). Regarding CSS, an elevated preoperative platelet count represented an independent prognostic factor of poor survival. Our findings strengthen the potential prognostic significance of preoperative thrombocytosis in patients with non-metastatic RCC. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Anemia - complications
- Anemia - diagnosis
- Anemia - pathology
- Carcinoma, Renal Cell - complications
- Carcinoma, Renal Cell - pathology
- Carcinoma, Renal Cell - surgery
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- Neoplasm Metastasis -
- Nephrectomy -
- Preoperative Period -
- Prognosis -
- Proportional Hazards Models -
- Thrombocytosis - complications
- Thrombocytosis - diagnosis
- Thrombocytosis - pathology
- Find related publications in this database (Keywords)
- Anemia
- leucocytosis
- prognosis
- renal cell carcinoma
- thrombocytosis