Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Delgado, G; Siekmeier, R; Krämer, BK; März, W; Kleber, ME.
Cotinine as a marker for risk prediction in the Ludwigshafen Risk and Cardiovascular Health Study.
Respir Physiol Neurobiol. 2015; 209(2):17-22
Doi: 10.1016/j.resp.2014.10.008
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Cotinine is one of the major metabolites of nicotine. The aim our study was to investigate cotinine as a marker for individual risk prediction in the Ludwigshafen Risk and Cardiovascular Health study. 840 samples had detectable cotinine measured using a radioimmunoassay (RIA nicotine metabolite, DPC Biermann GmbH). The distribution of risk factors across quartiles of cotinine or pack-years was analyzed by ANOVA and the association of cotinine and pack-years with mortality by Cox regression. Cotinine and pack-years both showed significant association with mortality in adjusted models with HRs (95% CI) of 1.30 (1.17-1.44) and 1.26 (1.13-1.42) comparing the third to the first tertile for cotinine and pack-years, respectively. Either cotinine or pack-years or self-reported smoking increased the area-under-the-curve significantly as compared to a basic model including other risk factors. Cotinine is a strong predictor of mortality in non-smokers as well as in smokers. As objectively measurable parameter cotinine would be preferable for risk prediction. Copyright © 2014 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Area Under Curve -
- Biomarkers - metabolism
- Cardiovascular Diseases - diagnosis
- Cardiovascular Diseases - etiology
- Cardiovascular Diseases - metabolism
- Cardiovascular Diseases - mortality
- Cotinine - metabolism
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Middle Aged -
- Prevalence -
- Prospective Studies -
- ROC Curve -
- Risk Factors -
- Sensitivity and Specificity -
- Smoking - metabolism
- Smoking - mortality
- Survival Analysis -
- Find related publications in this database (Keywords)
- Smoking
- Nicotine
- Cotinine
- Mortality