Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Waris, S; Winklhofer-Roob, BM; Roob, JM; Fuchs, S; Sourij, H; Rabbani, N; Thornalley, PJ.
Increased DNA dicarbonyl glycation and oxidation markers in patients with type 2 diabetes and link to diabetic nephropathy.
J Diabetes Res. 2015; 2015(2):915486-915486
Doi: 10.1155/2015/915486
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- Co-Autor*innen der Med Uni Graz
- Roob Johannes
- Sourij Harald
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- Abstract:
- The aim of this study was to assess the changes of markers of DNA damage by glycation and oxidation in patients with type 2 diabetes and the association with diabetic nephropathy. DNA oxidation and glycation adducts were analysed in plasma and urine by stable isotopic dilution analysis liquid chromatography-tandem mass spectrometry. DNA markers analysed were as follows: the oxidation adduct 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-OxodG) and glycation adducts of glyoxal and methylglyoxal--imidazopurinones GdG, MGdG, and N2-(1,R/S-carboxyethyl)deoxyguanosine (CEdG). Plasma 8-OxodG and GdG were increased 2-fold and 6-fold, respectively, in patients with type 2 diabetes, with respect to healthy volunteers. Median urinary excretion rates of 8-OxodG, GdG, MGdG, and CEdG were increased 28-fold, 10-fold, 2-fold, and 2-fold, respectively, in patients with type 2 diabetes with respect to healthy controls. In patients with type 2 diabetes, nephropathy was associated with increased plasma 8-OxodG and increased urinary GdG and CEdG. In a multiple logistic regression model for diabetic nephropathy, diabetic nephropathy was linked to systolic blood pressure and urinary CEdG. DNA oxidative and glycation damage-derived nucleoside adducts are increased in plasma and urine of patients with type 2 diabetes and further increased in patients with diabetic nephropathy.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - metabolism
- DNA Damage - physiology
- Deoxyguanosine - analogs & derivatives
- Deoxyguanosine - metabolism
- Diabetes Mellitus, Type 2 - metabolism
- Diabetic Nephropathies - metabolism
- Female -
- Glycation End Products, Advanced - metabolism
- Humans -
- Male -
- Middle Aged -
- Oxidation-Reduction -