Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fröhlich, E; Wahl, R.
Chemotherapy and chemoprevention by thiazolidinediones.
Biomed Res Int. 2015; 2015(3):845340-845340
Doi: 10.1155/2015/845340
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- Führende Autor*innen der Med Uni Graz
- Fröhlich Eleonore
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- Abstract:
- Thiazolidinediones (TZDs) are synthetic ligands of Peroxisome-Proliferator-Activated Receptor gamma (PPARγ). Troglitazone, rosiglitazone, and pioglitazone have been approved for treatment of diabetes mellitus type II. All three compounds, together with the first TZD ciglitazone, also showed an antitumor effect in preclinical studies and a beneficial effect in some clinical trials. This review summarizes hypotheses on the role of PPARγ in tumors, on cellular targets of TZDs, antitumor effects of monotherapy and of TZDs in combination with other compounds, with a focus on their role in the treatment of differentiated thyroid carcinoma. The results of chemopreventive effects of TZDs are also considered. Existing data suggest that the action of TZDs is highly complex and that actions do not correlate with cellular PPARγ expression status. Effects are cell-, species-, and compound-specific and concentration-dependent. Data from human trials suggest the efficacy of TZDs as monotherapy in prostate cancer and glioma and as chemopreventive agent in colon, lung, and breast cancer. TZDs in combination with other therapies might increase antitumor effects in thyroid cancer, soft tissue sarcoma, and melanoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - therapeutic use
- Humans -
- PPAR gamma - antagonists & inhibitors
- Thiazolidinediones - therapeutic use
- Thyroid Neoplasms - metabolism
- Thyroid Neoplasms - pathology
- Thyroid Neoplasms - prevention & control