Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kronsteiner, B; Peterbauer-Scherb, A; Grillari-Voglauer, R; Redl, H; Gabriel, C; van Griensven, M; Wolbank, S.
Human mesenchymal stem cells and renal tubular epithelial cells differentially influence monocyte-derived dendritic cell differentiation and maturation.
Cell Immunol. 2011; 267(1): 30-38.
Doi: 10.1016/j.cellimm.2010.11.001
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- GABRIEL Christian
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- Abstract:
- Mesenchymal stem cells (MSCs) possess immunosuppressive properties. But also fully differentiated human renal tubular epithelial cells (RTECs) are able to modulate T-cell proliferation in vitro. In this study we compared two MSC populations, human adipose derived stem cells (ASCs) and human amniotic mesenchymal stromal cells (hAMSCs), and RTECs regarding their potential to inhibit monocyte-derived dendritic cell (DC) differentiation and maturation in indirect co-culture. In the presence of hAMSCs and RTECs, monocytes stimulated to undergo DC differentiation were inhibited to acquire surface phenotype of immature and mature DCs. In contrast, ASCs showed only limited suppressive capacity. Secretion of IL-12p70 was suppressed in hAMSC co-cultures and high IL-10 levels were detected in all co-cultures. Prostaglandin E(2) was found in ASC and hAMSC co-cultures, whereas soluble human leukocyte antigen-G was highly elevated only in RTEC co-cultures. Thus, inhibition of DC generation by MSCs and RTECs might be mediated by different soluble factors. 2010 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cell Differentiation -
- Cell Survival -
- Coculture Techniques -
- Dendritic Cells - cytology Dendritic Cells - immunology
- Epithelial Cells - immunology
- Female -
- HLA Antigens - immunology
- HLA-G Antigens -
- Histocompatibility Antigens Class I - immunology
- Humans -
- Interleukin-10 - immunology Interleukin-10 - secretion
- Interleukin-12 - biosynthesis Interleukin-12 - immunology
- Kidney Tubules - immunology
- Mesenchymal Stromal Cells - immunology Mesenchymal Stromal Cells - secretion
- Middle Aged -
- Monocytes - cytology Monocytes - immunology
- Young Adult -
- Find related publications in this database (Keywords)
- Mesenchymal stem cells
- Renal tubular epithelial cells
- Dendritic cells
- Immunomodulation