Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Steinwender, C; Hofmann, R; Kypta, A; Kammler, J; Kerschner, K; Grund, M; Sihorsch, K; Gabriel, C; Leisch, F.
In-stent restenosis in bare metal stents versus sirolimus-eluting stents after primary coronary intervention for acute myocardial infarction and subsequent transcoronary transplantation of autologous stem cells.
Clin Cardiol. 2008; 31(8): 356-359.
Doi: 10.1002/clc.20235
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- Co-Autor*innen der Med Uni Graz
- GABRIEL Christian
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- Abstract:
- Following stenting for acute myocardial infarction, transcoronary transplantation of granulocyte-colony stimulating factor (G-CSF) mobilized autologous stem cells (ASC) has been shown to result in an increased in-stent restenosis rate of bare metal stents (BMS). This study sought to compare the extent of neointimal growth in BMS and sirolimus-eluting stents (SES) after primary implantation, and subsequent transcoronary transplantation of G-CSF mobilized stem cells. Patients with stenting of the left anterior descending coronary artery for acute anterior myocardial infarction were randomly assigned to receive a BMS or SES. Intracoronary stem cell injection was performed after G-CSF application for at least 4 d and cell apheresis. The angiograms obtained after cell transplantation and after 6 mo were analyzed by quantitative coronary angiography. We performed primary stenting and stem cell transplantion in 16 patients who received a BMS (n = 8) or an SES (n = 8). In 2 patients with a BMS, late stent thrombosis occurred after 58 d and 177 d, respectively. In the remaining patients, control angiography after 6 mo revealed in-stent restenosis of >50% in no patients with SES but in 4 patients with BMS (67%). Late lumen loss and in-stent plaque volume were significantly higher in patients with BMS compared with patients with SES. Compared with BMS, SES impair in-stent intima hyperplasia after stenting for acute myocardial infarction and transcoronary transplantation of G-CSF mobilized ASC.
- Find related publications in this database (using NLM MeSH Indexing)
- Coronary Restenosis - etiology
- Drug-Eluting Stents -
- Female -
- Granulocyte Colony-Stimulating Factor - physiology
- Humans -
- Male -
- Middle Aged -
- Myocardial Infarction - therapy
- Sirolimus - administration & dosage
- Stem Cell Transplantation -
- Stents -
- Find related publications in this database (Keywords)
- stem cells
- cytokines
- in-stent restenosis
- bare metal stents
- drug-eluting stents