Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Raggam, RB; Fischbach, LM; Prattes, J; Duettmann, W; Eigl, S; Reischies, F; Wölfler, A; Rabensteiner, J; Prueller, F; Krause, R; Hoenigl, M.
Detection of (1→3)-β-D-glucan in same-day urine and serum samples obtained from patients with haematological malignancies.
Mycoses. 2015; 58(7):394-398
Doi: 10.1111/myc.12328
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Raggam Reinhard Bernd
- Co-Autor*innen der Med Uni Graz
- Düttmann Wiebke
- Eigl Susanne
- Krause Robert
- Prattes Jürgen
- Prüller Florian
- Rabensteiner Jasmin
- Reischies-Meikl Frederike Marie Josefine
- Wölfler Albert
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- Abstract:
- Serum 1,3-beta-d-glucan (BDG) testing is an established diagnostic marker for invasive fungal infections (IFI) among patients with haematological malignancies. In contrast limited data exist regarding the application of urine BDG testing. Same-day midstream urine and serum screening samples were collected in adult patients with underlying haematological malignancies. A total of 80 urine samples from 46 patients were investigated: Twenty-six had positive corresponding serum BDG >120 pg ml(-1), 27 intermediate (60-80 pg ml(-1)), and 27 negative serum BDG (<25 pg ml(-1)). A significant positive correlation between BDG in serum and urine samples was observed (P = 0.025; r = 0.252). Sensitivity, specificity, positive predictive value and negative predictive value (compared with same-day serum results) were: 42%, 76%, 46%, 73% when using an 80 pg ml(-1) urine cut-off, and 35%, 96%, 82%, 75% for a 250 pg ml(-1) cut-off. Urine BDG seemed to be higher in samples obtained from patients with probable IFI (n = 13, median 145, IQR 22-253) compared to those from patients without IFI (n = 56, median 24, IQR 15-88) but the difference was not significant (P = 0.069). Overall correlation of same-day urine BDG and serum BDG was moderate. However, urine BDG testing may warrant further investigation in larger studies, as high-positive urine results correlated with high-positive corresponding serum levels and clinical performance was comparable to serum BDG. © 2015 Blackwell Verlag GmbH.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aspergillosis - diagnosis
- Aspergillosis - microbiology
- Candidiasis, Invasive - diagnosis
- Candidiasis, Invasive - microbiology
- Clinical Chemistry Tests -
- Female -
- Hematologic Neoplasms - complications
- Hematologic Neoplasms - microbiology
- Humans -
- Male -
- Middle Aged -
- Predictive Value of Tests -
- Sensitivity and Specificity -
- Young Adult -
- beta-Glucans - blood
- beta-Glucans - urine
- Find related publications in this database (Keywords)
- Invasive aspergillosis
- invasive candidiasis
- haematological malignancy
- beta-d-glucan