Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Fearon, WF; Yong, AS; Lenders, G; Toth, GG; Dao, C; Daniels, DV; Pijls, NHJ; De Bruyne, B.
The impact of downstream coronary stenosis on fractional flow reserve assessment of intermediate left main coronary artery disease: human validation.
JACC Cardiovasc Interv. 2015; 8(3):398-403 Doi: 10.1016/j.jcin.2014.09.027 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Toth-Gayor Gabor
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: The aim of this study was to determine the impact of downstream coronary stenosis in the left anterior descending coronary artery (LAD) or left circumflex coronary artery (LCx) on the assessment of fractional flow reserve (FFR) across an intermediate left main coronary artery (LMCA) stenosis in humans with the pressure wire positioned in the nondiseased downstream vessel. Accurate assessment of intermediate LMCA disease is critical for guiding decisions regarding revascularization. In theory, FFR across an intermediate LMCA stenosis will be affected by downstream disease, even if the pressure wire is positioned in the nondiseased downstream vessel. After percutaneous coronary intervention of the LAD, LCx, or both, an intermediate LMCA stenosis was created with a deflated balloon catheter. FFR was measured in the LAD and LCx coronary arteries before and after creation of downstream stenosis by inflating an angioplasty balloon within the newly placed stent. The true FFR (FFRtrue) of the LMCA, measured in the nondiseased downstream vessel in the absence of stenosis in the other vessel, was compared with the apparent FFR (FFRapp) measured in the presence of stenosis. In 25 patients, 91 pairs of measurements were made, 71 with LAD stenosis and 20 with LCx stenosis. FFRtrue of the LMCA was significantly lower than FFRapp (0.81 ± 0.08 vs. 0.83 ± 0.08, p < 0.001), although the numerical difference was small. This difference correlated with the severity of the downstream disease (r = 0.35, p < 0.001). In all cases in which FFRapp was >0.85, FFRtrue was >0.80. In most cases, downstream disease does not have a clinically significant impact on the assessment of FFR across an intermediate LMCA stenosis with the pressure wire positioned in the nondiseased vessel. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Angioplasty, Balloon, Coronary - instrumentation; Cardiac Catheterization - instrumentation; Cardiac Catheters -; Coronary Artery Disease - diagnosis; Coronary Artery Disease - physiopathology; Coronary Artery Disease - therapy; Coronary Stenosis - diagnosis; Coronary Stenosis - physiopathology; Coronary Stenosis - therapy; Coronary Vessels - physiopathology; Female -; Fractional Flow Reserve, Myocardial -; Humans -; Male -; Middle Aged -; Predictive Value of Tests -; Reproducibility of Results -; Severity of Illness Index -; Stents -; Transducers, Pressure -
Find related publications in this database (Keywords): coronary artery disease; fractional flow reserve; left main coronary artery