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SHR Neuro Cancer Cardio Lipid Metab Microb

Pyxaras, SA; Tu, S; Barbato, E; Barbati, G; Di Serafino, L; De Vroey, F; Toth, G; Mangiacapra, F; Sinagra, G; De Bruyne, B; Reiber, JH; Wijns, W.
Quantitative angiography and optical coherence tomography for the functional assessment of nonobstructive coronary stenoses: comparison with fractional flow reserve.
Am Heart J. 2013; 166(6):1010-1018 Doi: 10.1016/j.ahj.2013.08.016
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Co-authors Med Uni Graz: Toth-Gayor Gabor
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Abstract:: The purpose was to compare 3-dimensional quantitative coronary angiography (3D-QCA) with optical coherence tomography (OCT) for the functional assessment of nonobstructive coronary stenoses, as evaluated by fractional flow reserve (FFR). Fifty-five nonobstructive coronary stenoses (30%-50% diameter stenosis by visual estimation) were assessed in 36 patients using FFR, 2-dimensional QCA (2D-QCA), 3D-QCA, and OCT. Angiographic stenosis severity by 2D-QCA was 34% ± 13% diameter stenosis, and minimal lumen diameter (MLD) was 1.77 ± 0.58 mm. Fractional flow reserve values were 0.85 ± 0.10. Correlation coefficients between FFR and MLD or minimal lumen area (MLA) were highly significant for both 2D- and 3D-QCA (all P < .001), but higher R(2) values were observed for 3D-QCA measurements. Although significant, correlation coefficients between OCT and FFR data were weak (R(2) = 0.28, P = .001 for MLD and R(2) = 0.23, P = .003 for MLA). Correlation coefficients with FFR were significantly higher for 3D-QCA than for OCT (P values for MLD and MLA = .043 and .042, respectively). Nonobstructive stenoses with MLD >1.53 mm or MLA >2.43 mm(2) are unlikely to be hemodynamically significant. In nonobstructive coronary stenoses, anatomical parameters derived from 3D-QCA can best identify lesions with preserved FFR values. © 2013.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Cardiac Catheterization -; Coronary Angiography -; Coronary Stenosis - diagnosis; Coronary Stenosis - physiopathology; Female -; Fractional Flow Reserve, Myocardial -; Humans -; Imaging, Three-Dimensional -; Male -; Middle Aged -; Severity of Illness Index -; Tomography, Optical Coherence -