Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trana, C; Toth, G; Wijns, W; Barbato, E.
St. John's Wort in patients non-responders to clopidogrel undergoing percutaneous coronary intervention: a single-center randomized open-label trial (St. John's Trial).
J Cardiovasc Transl Res. 2013; 6(3):411-414
Doi: 10.1007/s12265-013-9455-2
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Toth-Gayor Gabor
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- Abstract:
- We assessed if St. John's Wort (SJW) improves platelet response in patients (pts) resistant to clopidogrel after percutaneous coronary intervention (PCI). Stable angina pts non-responders to 600 mg clopidogrel (P2Y12 reaction units (PRU) >240) were randomized (2:1) to SJW (n = 15) or placebo (n = 8). SJW (300 mg × 3/day) was administrated for 2 weeks after PCI. Platelet reactivity was assessed by VerifyNowTM before (BL), 2 (T1), and 4 weeks (T2) after PCI. PRU significantly changed during protocol in SJW (BL (316 ± 60) vs. T1 (170 ± 87) vs. T2 (220 ± 96), p < 0.0001) and placebo group (BL (288 ± 36) vs. T1 (236 ± 31) vs. T2 (236 ± 62), p = 0.046). Yet, PRU changes from BL were higher at T1 in SJW than in placebo group (Δ%, -47 ± 24 vs. -16 ± 15, p = 0.0033), with no differences at T2 between the groups (Δ%, -30 ± 29 vs. -17 ± 24, p = 0.30). Residual platelet reactivity improved with SJW during the first month post-PCI.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Analysis of Variance -
- Analysis of Variance -
- Blood Platelets - drug effects
- Blood Platelets - metabolism
- Chi-Square Distribution -
- Drug Resistance -
- Drug Therapy, Combination -
- Female -
- Humans -
- Hypericum -
- Male -
- Middle Aged -
- Percutaneous Coronary Intervention - adverse effects
- Phytotherapy -
- Plant Extracts - adverse effects
- Plant Extracts - therapeutic use
- Plants, Medicinal -
- Platelet Aggregation Inhibitors - adverse effects
- Platelet Aggregation Inhibitors - therapeutic use
- Platelet Function Tests -
- Predictive Value of Tests -
- Prospective Studies -
- Ticlopidine - adverse effects
- Ticlopidine - analogs & derivatives
- Ticlopidine - therapeutic use
- Time Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Clopidogrel
- Non-response
- St. John's Wort
- Platelet reactivity