Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Danzer, M; Polin, H; Pröll, J; Haunschmid, R; Hofer, K; Stabentheiner, S; Hackl, C; Kasparu, H; König, J; Hauser, H; Binder, M; Weiss, R; Gabriel, C; Krieger, O.
Clinical significance of HLA-E*0103 homozygosity on survival after allogeneic hematopoietic stem-cell transplantation.
Transplantation. 2009; 88(4): 528-532.
Doi: 10.1097/TP.0b013e3181b0e79e
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- GABRIEL Christian
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- Abstract:
- Hematopoietic stem-cell transplantation is a well-established treatment in various hematologic malignancies, but the outcome depends on disease relapse, infections, and the development and severity of acute and chronic graft-versus-host disease. Some evidence has revealed an important role for the nonclassical major histocompatibility complex class I molecules in transplantation, most notably human leukocyte antigen (HLA)-E. This study evaluates the impact of HLA-E alleles on transplantation outcome after HLA-matched allogeneic HSCT. We genotyped DNA for HLA-E polymorphism from 83 recipients and their respective donors by real-time polymerase chain reaction after melting curve analysis and compared the results with clinical outcome. HLA-E*0103 homozygous patients showed a higher probability of overall survival (P=0.003) and disease-free survival (P=0.001) in a univariate model. Cox regression analysis confirmed HLA-E*0103, 0103 (P=0.006; relative risk 1.12; 95% confidence interval 0.31-1.94) and early stage of disease (P=0.005; relative risk 1.16; 95% confidence interval 0.45-1.86) as independent factors improving overall survival. Moreover, homozygosity for HLA-E*0103 was associated with a significant decreased incidence of transplant-related mortality (P=0.01). We found an association between HLA-E*0103 homozygosity and the significant reduction of transplant-related mortality in related and unrelated HSCT. The risk of posttransplant complications was significantly reduced when the donor possesses the HLA-E*0103, 0103 genotype, and this was translated in a better overall survival.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adult -
- Aged -
- Base Sequence -
- Cohort Studies -
- DNA Primers - genetics
- Female -
- Genotype -
- Graft vs Host Disease - genetics Graft vs Host Disease - immunology
- HLA Antigens - genetics
- Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - mortality
- Heterozygote -
- Histocompatibility Antigens Class I -
- Homozygote -
- Humans -
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- Transplantation, Homologous -
- Young Adult -
- Find related publications in this database (Keywords)
- HLA-E
- Transplant-related mortality
- Graft-versus-host disease
- Hematopoietic stem-cell transplantation