Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Badr Eslam, R; Posch, F; Lang, IM; Gremmel, T; Eichelberger, B; Ay, C; Panzer, S.
Association of thrombin generation potential with platelet PAR-1 regulation and P-selectin expression in patients on dual antiplatelet therapy.
J Cardiovasc Transl Res. 2014; 7(1):126-132
Doi: 10.1007/s12265-013-9531-7
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Posch Florian
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- Abstract:
- We studied the association of thrombin generation potential with platelet protease activated receptor (PAR)-1 regulation and platelet activation in 52 stable coronary artery disease patients on continuous therapy with aspirin and clopidogrel (n = 42) or prasugrel (n = 10). Compared to controls, peak thrombin generation potential was elevated in only 11 patients (p > 0.05), while F1.2 was elevated in 26 patients (p < 0.0001). PAR-1 and thrombin inducible P-selectin expression were significantly elevated in patients compared to controls (p < 0.001). There were no significant correlations between levels of thrombin generation potential or F1.2 and PAR-1 regulation. However, there was a significant inverse correlation between levels of peak thrombin generation potential and in vitro thrombin-inducible expression of P-selectin (p = 0.002), suggesting in vivo depletion of platelet alpha granules due to ongoing platelet activation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aspirin - administration & dosage
- Biomarkers - blood
- Blood Platelets - drug effects Blood Platelets - metabolism
- Case-Control Studies -
- Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - drug therapy
- Female -
- Humans -
- Male -
- Middle Aged -
- P-Selectin - blood
- Peptide Fragments - blood
- Piperazines - administration & dosage
- Platelet Activation - drug effects
- Platelet Aggregation Inhibitors - administration & dosage
- Prasugrel Hydrochloride -
- Prothrombin -
- Receptor, PAR-1 - blood
- Thiophenes - administration & dosage
- Thrombin - metabolism
- Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives
- Find related publications in this database (Keywords)
- Thrombin generation
- Thienopyridine treatment
- PAR-1 regulation
- P-selectin