Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Panotopoulos, J; Posch, F; Alici, B; Funovics, P; Stihsen, C; Amann, G; Brodowicz, T; Windhager, R; Ay, C.
Hemoglobin, alkalic phosphatase, and C-reactive protein predict the outcome in patients with liposarcoma.
J Orthop Res. 2015; 33(5): 765-770.
Doi: 10.1002/jor.22827
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- Co-Autor*innen der Med Uni Graz
- Posch Florian
- Windhager Reinhard
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- Abstract:
- Data on prognostic biomarkers in soft tissue sarcomas are scarce. The aim of the study was to define prognostic markers in patients with a liposarcoma, a subtype of sarcoma derived from adipose tissue. We restrospectively reviewed 85 patients with liposarcoma treated at our department from May 1994 to October 2011. Kaplan-Meier curves, uni-, and multivariable Cox proportional hazard models and competing risk analysis were performed to evaluate the association between putative biomarkers with disease-specific and overall survival. We observed a significant association between both alkalic phosphatase (ALP; subhazard ratio [SHR] per 1 unit increase: 1.35; 95%CI 1.10-1.65; p = 0.005) and C-reactive protein (CRP; SHR per 1 mg/dl increase: 2,57; 95%CI 1.36-4,86; p = 0.004) with disease-specific survival. Hemoglobin (Hb) (HR per 1 g/dl increase: 065; 95%CI 0.48-0.87; p = 0.003) was associated with overall survival. These associations prevailed after multivariable adjustment for AJCC tumor stage. This study identifies CRP and ALP as novel independent predictors of disease-specific survival in patients with liposarcoma. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Alkaline Phosphatase - blood
- Alkaline Phosphatase - epidemiology
- Biomarkers - blood
- C-Reactive Protein - metabolism
- Female -
- Hemoglobins - metabolism
- Humans -
- Liposarcoma - blood Liposarcoma - mortality
- Male -
- Middle Aged -
- Retrospective Studies -
- Young Adult -
- Find related publications in this database (Keywords)
- liposarcoma
- prognosis
- CRP
- alkalic phospahtase
- hemoglobin