Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Watzka, SB; Posch, F; Pass, HI; Huflejt, M; Bernhard, D; Hannigan, GE; Müller, MR.
Detection of integrin-linked kinase in the serum of patients with malignant pleural mesothelioma.
J Thorac Cardiovasc Surg. 2011; 142(2):384-389
Doi: 10.1016/j.jtcvs.2011.04.034
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- Co-Autor*innen der Med Uni Graz
- Posch Florian
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- Abstract:
- Integrin-linked kinase, which is relevant to neoplastic transformation, is highly expressed in malignant pleural mesothelioma. Recently, detection of integrin-linked kinase in serum of patients with ovarian cancer has been reported. This study asks whether integrin-linked kinase can also be detected in serum of patients with malignant pleural mesothelioma and whether serum level has diagnostic or prognostic relevance for that disease. A sandwich enzyme-linked immunosorbent assay was designed to detect integrin-linked kinase and applied to serum samples from 46 patients with malignant pleural mesothelioma, 98 patients with other malignant chest disease, and 23 patients with benign chest disease. Integrin-linked kinase serum concentration and clinical data were correlated statistically. Median serum integrin-linked kinase concentration was significantly higher in malignant pleural mesothelioma (8.89 ng/mL) than in other malignant chest disease (0.66 ng/mL) or benign chest disease (0.78 ng/mL, P < .001). There was no relevant correlation of serum integrin-linked kinase with cell lysis parameters (R(2) < 0.1). Serum integrin-linked kinase concentration greater than 2.48 ng/mL had diagnostic sensitivity of 80%, specificity of 95%, positive predictive value of 85.7%, negative predictive value of 92.7%, and overall accuracy of 91% for distinction between malignant pleural mesothelioma and other diseases. Serum integrin-linked kinase concentration in malignant pleural mesothelioma was independent of histologic subtype or asbestos exposure. There was no statistically significant impact of serum integrin-linked kinase concentration on prognosis. Integrin-linked kinase can be detected in serum of patients with malignant pleural mesothelioma and may be a diagnostic marker for the disease. Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - blood
- Cell Transformation, Neoplastic -
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Humans -
- Male -
- Mesothelioma - blood Mesothelioma - diagnosis Mesothelioma - enzymology
- Middle Aged -
- Pleural Neoplasms - blood Pleural Neoplasms - diagnosis Pleural Neoplasms - enzymology
- Prognosis -
- Protein-Serine-Threonine Kinases - blood
- Sensitivity and Specificity -