Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gebhart, J; Posch, F; Koder, S; Perkmann, T; Quehenberger, P; Zoghlami, C; Ay, C; Pabinger, I.
Increased mortality in patients with the lupus anticoagulant: the Vienna Lupus Anticoagulant and Thrombosis Study (LATS).
Blood. 2015; 125(22): 3477-3483.
Doi: 10.1182/blood-2014-11-611129
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- Co-Autor*innen der Med Uni Graz
- Posch Florian
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- Abstract:
- Data on the clinical course of lupus anticoagulant (LA)-positive individuals with or without thrombotic manifestations or pregnancy complications are limited. To investigate mortality rates and factors that might influence mortality, we conducted a prospective observational study of LA-positive individuals. In total, 151 patients (82% female) were followed for a median of 8.2 years; 30 of the patients (20%) developed 32 thromboembolic events (15 arterial and 17 venous events) and 20 patients (13%) died. In univariable analysis, new onset of thrombosis (hazard ratio [HR] = 8.76; 95% confidence interval [CI], 3.46-22.16) was associated with adverse survival. Thrombosis remained a strong adverse prognostic factor after multivariable adjustment for age and hypertension (HR = 5.95; 95% CI, 2.43-14.95). Concomitant autoimmune diseases, anticoagulant treatment at baseline, or positivity for anticardiolipin- or anti-β2-glycoprotein I antibodies were not associated with mortality. In a relative survival analysis, our cohort of LA positives showed a persistently worse survival in comparison with an age-, sex-, and study-inclusion-year-matched Austrian reference population. The cumulative relative survival was 95.0% (95% CI, 88.5-98.8) after 5 years and 87.7% (95% CI, 76.3-95.6) after 10 years. We conclude that occurrence of a thrombotic event is associated with higher mortality in patients with LA. Consequently, the prevention of thromboembolic events in LA positives might improve survival. © 2015 by The American Society of Hematology.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anticoagulants - therapeutic use
- Antiphospholipid Syndrome - blood Antiphospholipid Syndrome - complications Antiphospholipid Syndrome - mortality
- Antiphospholipid Syndrome - epidemiology
- Case-Control Studies -
- Cause of Death -
- Female -
- Follow-Up Studies -
- Humans -
- Lupus Coagulation Inhibitor - blood
- Male -
- Middle Aged -
- Pregnancy -
- Pregnancy Complications - epidemiology
- Survival Analysis -
- Thrombosis - blood Thrombosis - complications Thrombosis - mortality