Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hagel, V; Mateescu, M; Southan, A; Wegner, SV; Nuss, I; Haraszti, T; Kleinhans, C; Schuh, C; Spatz, JP; Kluger, PJ; Bach, M; Tussetschläger, S; Tovar, GE; Laschat, S; Boehm, H.
Desmosine-inspired cross-linkers for hyaluronan hydrogels.
Sci Rep. 2013; 3(12):2043-2043
Doi: 10.1038/srep02043
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- Co-Autor*innen der Med Uni Graz
- Kleinhans Claudia
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- Abstract:
- We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid cross-linkers are based on pyridinium salts (as in desmosine) and can connect two polymer backbones. Generally, the obtained semi-synthetic hydrogels are form-stable, can withstand repeated stress, have a large linear-elastic range, and show strain stiffening behavior typical for biopolymer networks. In addition, it is possible to introduce a positive charge to the core of the cross-linker without affecting the gelation efficiency, or consequently the network connectivity. However, the mechanical properties strongly depend on the charge of the cross-linker. The properties of the presented hydrogels can thus be tuned in a range important for engineering of soft tissues by controlling the cross-linking density and the charge of the cross-linker.
- Find related publications in this database (using NLM MeSH Indexing)
- Biocompatible Materials - chemistry
- Cross-Linking Reagents - chemistry
- Desmosine - chemistry
- Hyaluronic Acid - chemistry
- Hydrogels - chemistry
- Materials Testing -
- Mechanical Processes -
- Molecular Structure -
- Tissue Engineering -