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SHR Neuro Cancer Cardio Lipid Metab Microb
Schweintzger, NA; Bambach, I; Reginato, E; Mayer, G; Limón-Flores, AY; Ullrich, SE; Byrne, SN; Wolf, P.
Mast cells are required for phototolerance induction and scratching abatement.
Exp Dermatol. 2015; 24(7):491-496
Doi: 10.1111/exd.12687
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Schweintzger Nina
- Wolf Peter
- Co-authors Med Uni Graz
- Mayer Gerlinde
- Perchthaler Isabella
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- Abstract:
- Dermal mast cells protect the skin from inflammatory effects of ultraviolet (UV) radiation and are required for UV-induced immune suppression. We sought to determine a potential mechanistic role of mast cells in reducing the sensitivity to UV radiation (i.e. phototolerance induction) through photohardening. We administered single UV exposures as well as a chronic UV irradiation regime to mast cell-deficient Kit(W-Sh/W-Sh) mice and their controls. The chronic irradiation protocol was similar to that given for prophylaxis in certain photodermatoses in humans. Compared to controls, UV-exposed Kit(W-Sh/W-Sh) mice were more susceptible to epidermal hyperplasia and dermal oedema which was linked to blood vessel dilation. Unexpectedly, Kit(W-Sh/W-Sh) mice exhibited an excessive scratching behaviour following broadband UVB plus UVA or solar simulated UV irradiation at doses far below their minimal skin-swelling dose. Protection from this UV-induced scratching phenotype was dependent on mast cells, as engraftment of bone marrow-derived cultured mast cells abated it entirely. Kit(W-Sh/W-Sh) mice were entirely resistant to phototolerance induction by photohardening treatment. Compared to controls, these mice also showed reduced numbers of regulatory T cells and neutrophils in the skin 24 h after UV irradiation. While it is well known that mast cell-deficient mice are resistant to UV-induced immune suppression, we have discovered that they are prone to develop photo-itch and are more susceptible to UV-induced epidermal hyperplasia and skin oedema. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Edema - etiology
- Edema - immunology
- Hyperplasia -
- Immune Tolerance - radiation effects
- Mast Cells - immunology
- Mast Cells - physiology
- Mast Cells - radiation effects
- Mice -
- Mice, Inbred C57BL -
- Mice, Transgenic -
- Neutrophils - immunology
- Neutrophils - radiation effects
- Proto-Oncogene Proteins c-kit - genetics
- Proto-Oncogene Proteins c-kit - immunology
- Pruritus - etiology
- Pruritus - immunology
- Pruritus - physiopathology
- Skin - immunology
- Skin - pathology
- Skin - radiation effects
- T-Lymphocytes, Regulatory - immunology
- T-Lymphocytes, Regulatory - radiation effects
- Ultraviolet Rays - adverse effects
- Vasodilation - immunology
- Vasodilation - radiation effects
- Find related publications in this database (Keywords)
- immunosuppression
- mast cells
- photohardening
- scratching phenotype
- Tregs