Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Murr, C; Grammer, TB; Kleber, ME; Meinitzer, A; März, W; Fuchs, D.
Low serum tryptophan predicts higher mortality in cardiovascular disease.
Eur J Clin Invest. 2015; 45(3):247-254
Doi: 10.1111/eci.12402
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- Co-Autor*innen der Med Uni Graz
- März Winfried
- Meinitzer Andreas
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- Abstract:
- The essential amino acid tryptophan is required for protein synthesis and formation of the neurotransmitter serotonin and may exert immunoregulatory functions. An accelerated tryptophan breakdown rate is associated with inflammation and immune activation. Serum concentrations of free tryptophan, neopterin and high-sensitivity C-reactive protein (hsCRP) were measured in 1196 patients with coronary artery disease (CAD) derived from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study. Tryptophan concentrations did not differ between patients with (mean ± SD: 40.1 ± 9.8 μM) or without (42.3 ± 23.9 μM; not significant, Welch's test) angiographic CAD, but patients with CAD had higher neopterin (9.1 ± 8.2 nM) and hsCRP (9.3 ± 18.5 mg/L) concentrations compared to patients without (neopterin: 7.6 ± 4.7 nM, hsCRP: 5.8 ± 7.6 mg/L; both P < 0.0001). There existed an inverse correlation between serum tryptophan and neopterin (Spearman's rank correlation: rs = -0.273) and hsCRP (rs = -0.163; both P < 0.0001) concentrations. Median observation time was 10.5 years, and 385 patients had died, including 244 patients due to cardiovascular and 132 due to noncardiovascular causes. After adjustments for cardiovascular risk factors and other possible confounders, the hazard ratio (with 95% CI) in the first tryptophan quartile of the study population was 1.51 (1.19-1.90; P = 0.0006) for total mortality, 1.41 (1.05-1.89; P = 0.0224) for cardiovascular and 1.79 (1.20-2.67; P = 0.0042) for noncardiovascular mortalities, respectively, thus indicating a significantly higher risk of death in patients with tryptophan concentrations < 34 μM. Low serum tryptophan in patients with CAD is associated with immune activation and indicates reduced life expectancy. © 2015 Stichting European Society for Clinical Investigation Journal Foundation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Age Factors -
- Aged -
- Aged, 80 and over -
- C-Reactive Protein - metabolism
- Cardiovascular Diseases - blood
- Cardiovascular Diseases - immunology
- Cardiovascular Diseases - mortality
- Case-Control Studies -
- Female -
- Humans -
- Immunity - immunology
- Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism
- Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology
- Life Expectancy -
- Male -
- Middle Aged -
- Neopterin - metabolism
- Survival Analysis -
- Tryptophan - deficiency
- Tryptophan - immunology
- Young Adult -
- Find related publications in this database (Keywords)
- Coronary artery disease
- C-reactive protein
- neopterin
- tryptophan