Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Delgado, G; Siekmeier, R; Grammer, TB; Boehm, BO; März, W; Kleber, ME.
Alterations in the coagulation system of active smokers from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
ADVAN EXPERIMENT MED BIOL. 2015; 832(1): 9-14.
Doi: 10.1007/5584_2014_5
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- Smoking is an important and preventable risk factor of cardiovascular diseases with effects on blood coagulation. Our aim was to analyze the influence of smoking on coagulation parameters. Concentrations or activities of blood coagulation factors were compared in 777 active smokers and 1,178 lifetime non-smokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. The association with mortality was examined using Cox regression. The findings show that AS had a tendency toward thrombosis. They displayed significantly higher values for fibrinogen, soluble fibrinogen, factor XIII, and tissue factor pathway inhibitor; whereas FVII, FVIII, FXII, von Willebrand factor (vWF), and thrombomodulin were decreased. The Cox regression analysis showed fibrinogen, FVIII, vWF, thrombomodulin, and tissue factor pathway inhibitor to be independent risk factors for mortality in active smokers with hazard ratios of 1.16 (95% CI: 1.02-1.31), 1.40 (1.22-1.59), 1.37 (1.22-1.56), 1.19 (1.07-1.31), and 1.22 (1.06-1.40) per increase of one standard deviation. We conclude that active smokers have an increased thrombogenic potential associated with significant changes in the coagulation system. Individual parameters of the coagulation system are independent predictors of mortality. Therefore, parameters of the coagulation system, apart from other risk factors for cardiovascular disease (e.g., lipids or life-style) should be determined for risk prediction in active smokers.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Blood Coagulation -
- Blood Coagulation Factors - metabolism
- Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality
- Case-Control Studies -
- Female -
- Humans -
- Male -
- Middle Aged -
- Proportional Hazards Models -
- Risk Factors -
- Smoking - adverse effects
- Survival Analysis -
- Find related publications in this database (Keywords)
- Cardiovascular disease
- Hemostasis
- Mortality
- Smoking
- Thrombosis