Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vogl, L; Pohlhammer, J; Meinitzer, A; Rantner, B; Stadler, M; Peric, S; Hammerer-Lercher, A; Klein-Weigel, P; Fraedrich, G; Kronenberg, F; Kollerits, B.
Serum concentrations of L-arginine and L-homoarginine in male patients with intermittent claudication: a cross-sectional and prospective investigation in the CAVASIC Study.
Atherosclerosis. 2015; 239(2):607-614
Doi: 10.1016/j.atherosclerosis.2015.02.019
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Meinitzer Andreas
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- Abstract:
- High serum concentrations of l-arginine and l-homoarginine increase nitric oxide (NO) availability and thereby improve endothelial function. Information about the association of these markers with peripheral arterial disease (PAD) and related outcomes is sparse. l-arginine, its metabolites and l-homoarginine were analyzed in the CAVASIC Study including 232 male patients diagnosed with intermittent claudication and 246 age- and diabetes-matched controls. After the baseline investigation PAD patients were prospectively followed (median 7 years). The association of these markers with symptomatic PAD at baseline, incident cardiovascular events and all-cause mortality was assessed. At baseline each increase of ln-l-homoarginine and l-arginine by one standard deviation was associated with symptomatic PAD: OR=0.75, 95%CI 0.59-0.96, P=0.02 and OR=1.36, 95%CI 1.07-1.73, P=0.01, respectively (both models adjusted for ln-CRP, GFR, HDL cholesterol, and current smoking). Only l-arginine remained significant after additional adjustment for ln-NT-proBNP and hs-cTnT: OR=1.49, P=0.002. In the Cox regression analysis elevated ln-l-homoarginine significantly reduced the risk to die (n=38) even independent from ln-NT-proBNP and hs-cTnT: HR=0.59, 95%CI 0.41-0.84, P=0.004. l-arginine was significantly predicting incident cardiovascular events (n=65): HR=1.68, 95%CI 1.35-2.10, P < 0.001. This study in male patients with intermittent claudication and age- and diabetes-matched controls showed an association of l-homoarginine and l-arginine with PAD. During follow-up, l-arginine was associated with incident cardiovascular events probably due to its primary role in NO metabolism and impact on endothelial integrity. l-homoarginine was related to all-cause mortality implying a broader role in metabolic processes besides endothelial function. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Arginine - blood
- Arginine -
- Biomarkers - blood
- Case-Control Studies -
- Cause of Death -
- Chi-Square Distribution -
- Cross-Sectional Studies -
- Disease Progression -
- Homoarginine - blood
- Humans -
- Intermittent Claudication - blood
- Intermittent Claudication - diagnosis
- Intermittent Claudication - mortality
- Male -
- Middle Aged -
- Odds Ratio -
- Peripheral Arterial Disease - blood
- Peripheral Arterial Disease - diagnosis
- Peripheral Arterial Disease - mortality
- Prognosis -
- Proportional Hazards Models -
- Prospective Studies -
- Risk Factors -
- Time Factors -
- Find related publications in this database (Keywords)
- Peripheral arterial disease
- Cardiovascular disease
- Mortality
- L-homoarginine
- L-arginine
- ADMA
- SDMA