Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Chiesa, C; Pacifico, L; Natale, F; Hofer, N; Osborn, JF; Resch, B.
Fetal and early neonatal interleukin-6 response.
Cytokine. 2015; 76(1):1-12
Doi: 10.1016/j.cyto.2015.03.015
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- Co-Autor*innen der Med Uni Graz
- Hofer Nora
- Resch Bernhard
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- Abstract:
- In 1998, a systemic fetal cytokine response, defined as a plasma interleukin-6 (IL-6) value above 11 pg/mL, was reported to be a major independent risk factor for the subsequent development of neonatal morbid events even after adjustments for gestational age and other confounders. Since then, the body of literature investigating the use of blood concentrations of IL-6 as a hallmark of the fetal inflammatory response syndrome (FIRS), a diagnostic marker of early-onset neonatal sepsis (EONS) and a risk predictor of white matter injury (WMI), has grown rapidly. In this article, we critically review: IL-6 biological functions; current evidence on the association between IL-6, preterm birth, FIRS and EONS; IL-6 reference intervals and dynamics in the early neonatal period; IL-6 response during the immediate postnatal period and perinatal confounders; accuracy and completeness of IL-6 diagnostic studies for EONS (according to the Standards for Reporting of Diagnostic Accuracy statement); and recent breakthroughs in the association between fetal blood IL-6, EONS, and WMI. Copyright © 2015 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Data Accuracy -
- Female -
- Fetal Blood - immunology
- Fetus - immunology
- Gestational Age -
- Humans -
- Infant, Newborn -
- Interleukin-6 - blood
- Interleukin-6 - immunology
- Interleukin-6 - physiology
- Leukoencephalopathies - etiology
- Pregnancy -
- Premature Birth - immunology
- Reference Values -
- Sepsis - diagnosis
- Sepsis - etiology
- Sepsis - immunology
- Systemic Inflammatory Response Syndrome - blood
- Find related publications in this database (Keywords)
- Interleukin-6
- Fetal inflammatory response syndrome
- Early-onset neonatal sepsis
- Reference intervals
- Diagnostic accuracy