Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dalpiaz, O; Pichler, M; Mrsic, E; Reitz, D; Krieger, D; Venturino, L; Bezan, A; Stojakovic, T; Pummer, K; Zigeuner, R; Hutterer, GC.
Preoperative serum-gamma-glutamyltransferase (GGT) does not represent an independent prognostic factor in a European cohort of patients with non-metastatic renal cell carcinoma.
J Clin Pathol. 2015; 68(7):547-551
Doi: 10.1136/jclinpath-2014-202683
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Dalpiaz Orietta
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Hutterer Georg
- Pummer Karl
- Stojakovic Tatjana
- Terbuch Angelika
- Zigeuner Richard
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- Abstract:
- Increasing evidence suggests that the serum-gamma-glutamyltransferase (GGT) might correlate with tumour development and growth rates in various human cancer types. Thus, we decided to investigate the potential prognostic impact of the preoperatively assessed serum-GGT in a European cohort of patients with non-metastatic renal cell carcinoma (RCC). Clinicopathological data from 700 consecutive patients with non-metastatic RCC, operated between 2000 and 2010 at a single tertiary academic centre, were evaluated retrospectively. Preoperative serum-GGT was assessed 1 day before surgery. Patients were categorised using a serum-GGT cut-off value of 40 U/L according to a calculation by receiver operating curve analysis. Patients' cancer-specific survival (CSS), metastasis-free survival (MFS), as well as overall survival (OS) were assessed using the Kaplan-Meier method and Cox proportional models. In univariate analysis, an elevated preoperative serum-GGT level (<40 U/L vs ≥40 U/L) was statistically significantly associated with a shorter MFS (HR=1.517, 95% CI 1.047 to 2.197, p=0.027). In multivariate analyses, pathological T-Stage (pT-1 vs pT-2-4, HR=2.065, 95% CI 1.665 to 2.560), tumour grade (G-1+G-2 vs G-3+G-4, HR=1.671, 95% CI 1.261 to 2.213), as well as the presence of histological tumour necrosis (No vs Yes, HR=2.031, 95% CI 1.355 to 3.046) were independent predictors of MFS in patients with RCC, whereas the preoperative serum-GGT failed to reach independent predictor status (<40 U/L vs ≥40 U/L, HR=1.156, 95% CI 0.791 to 1.690). No prognostic role for GGT in OS or CSS could be identified. In the cohort studied, patients with an elevated (≥40 U/L) preoperative serum-GGT had a subsequently shorter MFS only in univariate analysis. In contrast to previous studies, our data failed to demonstrate preoperatively assessed serum-GGT as an independent prognostic factor in patients with non-metastatic RCC. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Area Under Curve -
- Area Under Curve - epidemiology
- Biomarkers, Tumor - blood
- Carcinoma, Renal Cell - blood
- Carcinoma, Renal Cell - enzymology
- Carcinoma, Renal Cell - ethnology
- Carcinoma, Renal Cell - mortality
- Carcinoma, Renal Cell - pathology
- Disease-Free Survival -
- European Continental Ancestry Group -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Kidney Neoplasms - blood
- Kidney Neoplasms - enzymology
- Kidney Neoplasms - ethnology
- Kidney Neoplasms - mortality
- Kidney Neoplasms - pathology
- Male -
- Multivariate Analysis -
- Necrosis -
- Neoplasm Grading -
- Neoplasm Staging -
- Predictive Value of Tests -
- Proportional Hazards Models -
- ROC Curve -
- Retrospective Studies -
- Risk Factors -
- Time Factors -
- Up-Regulation -
- gamma-Glutamyltransferase - blood