Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Frudinger, A; Pfeifer, J; Paede, J; Kolovetsiou-Kreiner, V; Marksteiner, R; Halligan, S.
Autologous skeletal-muscle-derived cell injection for anal incontinence due to obstetric trauma: a 5-year follow-up of an initial study of 10 patients.
Colorectal Dis. 2015; 17(9): 794-801.
Doi: 10.1111/codi.12947
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Frudinger Andrea
- Co-Autor*innen der Med Uni Graz
- Kolovetsiou-Kreiner Vassiliki
- Pfeifer Johann
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- Abstract:
- Our aim was to determine whether the benefits of autologous skeletal-muscle-derived cell injection to treat obstetric anal incontinence are sustained at 5 years. An observational study was performed of 10 women suffering from obstetric anal incontinence refractory to non-surgical therapy. Autologous skeletal-muscle-derived cells were injected into the external sphincter defect under ultrasound guidance. Incontinence diaries and quality of life questionnaires were obtained pre-implantation and annually after implantation for 5 years. Anal physiology testing was performed before implantation and at 1, 2 and 5 years after implantation. The end-points included were adverse events, Wexner incontinence scores, incontinence episodes, anal squeeze pressures and quality of life over 5 years. An independent statistician used multilevel linear regression to analyse changes in repeated measures over time. Any skewed distributions were log transformed prior to analysis. No procedure-related adverse events occurred and haematological and biochemical parameters were normal during the 5-year period. There were sustained significant improvements in the Wexner incontinence score and reduced frequency of defaecation and number of incontinence episodes (all comparisons P < 0.001). Anal resting and squeeze pressures showed sustained improvement (all P < 0.001) and quality of life improved overall (P < 0.001), including all submeasures studied (P < 0.001). Autologous skeletal-muscle-derived cells to treat obstetric anal incontinence resulted in sustained improvement in incontinence episodes, physiological measurements of anal function and quality of life at 5 years. Colorectal Disease © 2015 The Association of Coloproctology of Great Britain and Ireland.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Anal Canal - injuries
- Anal Canal - physiopathology
- Defecation -
- Delivery, Obstetric - adverse effects
- Fecal Incontinence - etiology
- Fecal Incontinence - therapy
- Female -
- Follow-Up Studies -
- Health Surveys -
- Humans -
- Injections, Intramuscular -
- Manometry -
- Middle Aged -
- Myoblasts, Skeletal - transplantation
- Quality of Life -
- Severity of Illness Index -
- Transplantation, Autologous -
- Find related publications in this database (Keywords)
- anal
- functional
- incontinence