Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Christova, M; Rafolt, D; Gallasch, E.
Cumulative effects of anodal and priming cathodal tDCS on pegboard test performance and motor cortical excitability.
Behav Brain Res. 2015; 287(19):27-33
Doi: 10.1016/j.bbr.2015.03.028
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Christova Monica
- Co-Autor*innen der Med Uni Graz
- Gallasch Eugen
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- Abstract:
- Transcranial direct current stimulation (tDCS) protocols applied over the primary motor cortex are associated with changes in motor performance. This transcranial magnetic stimulation (TMS) study examines whether cathodal tDCS prior to motor training, combined with anodal tDCS during motor training improves motor performance and off-line learning. Three study groups (n=36) were trained on the grooved pegboard test (GPT) in a randomized, between-subjects design: SHAM-sham stimulation prior and during training, STIM1-sham stimulation prior and atDCS during training, STIM2-ctDCS stimulation prior and atDCS during training. Motor performance was assessed by GPT completion time and retested 14 days later to determine off-line learning. Cortical excitability was assessed via TMS at baseline (T0), prior training (T1), after training (T2), and 60 min after training (T3). Motor evoked potentials (MEP) were recorded from m. abductor pollicis brevis of the active left hand. GPT completion time was reduced for both stimulated groups compared to SHAM. For STIM2 this reduction in time was significantly higher than for STIM1 and further off-line learning occurred after STIM2. After ctDCS at T1, MEP amplitude and intracortical facilitation was decreased and intracortical inhibition was increased. After atDCS at T2, an opposite effect was observed for STIM1 and STIM2. For STIM2 these neuromodulatory effects were retained until T3. It is concluded that application of atDCS during the training improves pegboard performance and that additional priming with ctDCS has a positive effect on off-line learning. These cumulative behavioral gains were indicated by the preceding neuromodulatory changes. Copyright © 2015 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Evoked Potentials, Motor -
- Female -
- Humans -
- Male -
- Motor Activity -
- Motor Cortex - physiology
- Muscle, Skeletal - physiology
- Neuronal Plasticity -
- Psychomotor Performance - physiology
- Transcranial Direct Current Stimulation - methods
- Young Adult -
- Find related publications in this database (Keywords)
- Skill learning
- Motor cortex
- Neuroplasticity
- Procedural memory
- tDCS
- TMS