Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Czembirek, C; Eder-Czembirek, C; Erovic, BM; Turhani, D; Selzer, E; Thurnher, D.
Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head and neck cancer cell lines.
Oncol Rep. 2005; 14(6):1523-1526
Doi: 10.3892/or.14.6.1523
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- Although head and neck cancer is a common malignancy, investigations have not yet improved the poor prognosis of patients. Therefore, it is important to find new cancer treatment modalities. Recent studies showed that cyclooxygenase, especially its isoform cyclooxygenase-2, is involved in tumorigenesis, tumor growth and metastasis. Inhibition of this enzyme by cyclooxygenase inhibitors has been shown to be antiproliferative in numerous cancer cell lines. The aim of this study was to investigate if the selective cyclooxygenase-2 inhibitor nimesulide could enhance cytotoxicity of the standard chemotherapeutic agent cisplatin. Head and neck squamous cell cancer cells were incubated with nimesulide and/or cisplatin, and counted after 24, 48 and 72 h treatment. Visualization of apoptotic cells was done by immunohistochemistry. We demonstrated that nimesulide inhibits the cytotoxic effect of cisplatin in HNSCC cells. Therefore, COX-2 inhibitor nimesulide may not be a good partner for cisplatin in combination therapy for cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - pharmacology
- Apoptosis - drug effects
- Cell Line, Tumor -
- Cell Proliferation - drug effects
- Cell Survival - drug effects
- Cisplatin - pharmacology
- Cyclooxygenase 2 - metabolism
- Cyclooxygenase Inhibitors - pharmacology
- Dose-Response Relationship, Drug -
- Drug Antagonism -
- Drug Synergism -
- Head and Neck Neoplasms - drug therapy
- Head and Neck Neoplasms - metabolism
- Head and Neck Neoplasms - pathology
- Humans -
- Immunohistochemistry -
- Keratins - analysis
- Sulfonamides - pharmacology
- Time Factors -
- Find related publications in this database (Keywords)
- cyclooxygenase-2
- COX-2
- head and neck cancer
- nimesulide
- cisplatin