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Erovic, BM; Pelzmann, M; Turhani, D; Pammer, J; Niederberger, V; Neuchrist, C; Grasl, MCh; Thurnher, D.
Differential expression pattern of cyclooxygenase-1 and -2 in head and neck squamous cell carcinoma.
Acta Otolaryngol. 2003; 123(8):950-953 Doi: 10.1080/00016480310016118
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Leading authors Med Uni Graz: Thurnher Dietmar
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Abstract:: The enzyme cyclooxygenase catalyzes the first step of the synthesis of prostanoids Cyclooxygenase has been shown to exist in two distinct isoforms: cyclooxygenase-1 is constitutively expressed as a housekeeping enzyme in most tissues whereas the inducible cyclooxygenase-2 has been reported to be involved in inflammatory processes and in the carcinogenesis of squamous cell carcinoma. The aim of this study was to investigate the distribution patterns of cyclooxygenase-1 and -2 in peritumoral lymphocytic infiltrates and tumor cells of head and neck carcinoma. Immunohistochemical analysis was performed using paraffin-embedded tumor specimens from 24 patients suffering from oropharyngeal, hypopharyngeal and oral squamous cell carcinomas. We observed that cyclooxygenase-2 immunoreactivity, compared to that of cyclooxygenase-1, was significantly increased in peritumoral lymphocytic infiltrates as well as in tumor cells. The expression of cyclooxygenase-2 in both tumor specimens and the surrounding peritumoral lymphocytic infiltrates supports the hypothesis that cyclooxygenase may be one of several important links between chronic inflammation and carcinogenesis.
Find related publications in this database (using NLM MeSH Indexing): Carcinoma, Squamous Cell - enzymology; Carcinoma, Squamous Cell - pathology; Cyclooxygenase 1 -; Cyclooxygenase 2 -; Female -; Humans -; Isoenzymes - metabolism; Lymphocytes, Tumor-Infiltrating - enzymology; Male -; Membrane Proteins -; Mouth Neoplasms - enzymology; Mouth Neoplasms - pathology; Pharyngeal Neoplasms - enzymology; Pharyngeal Neoplasms - pathology; Prostaglandin-Endoperoxide Synthases - metabolism
Find related publications in this database (Keywords): Cox-1; Cox-2; head and neck squamous cell carcinoma; peritumoral lymphocytic infiltrate