Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Erovic, BM; Pelzmann, M; Turhani, D; Pammer, J; Niederberger, V; Neuchrist, C; Grasl, MCh; Thurnher, D.
Differential expression pattern of cyclooxygenase-1 and -2 in head and neck squamous cell carcinoma.
Acta Otolaryngol. 2003; 123(8):950-953
Doi: 10.1080/00016480310016118
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- The enzyme cyclooxygenase catalyzes the first step of the synthesis of prostanoids Cyclooxygenase has been shown to exist in two distinct isoforms: cyclooxygenase-1 is constitutively expressed as a housekeeping enzyme in most tissues whereas the inducible cyclooxygenase-2 has been reported to be involved in inflammatory processes and in the carcinogenesis of squamous cell carcinoma. The aim of this study was to investigate the distribution patterns of cyclooxygenase-1 and -2 in peritumoral lymphocytic infiltrates and tumor cells of head and neck carcinoma. Immunohistochemical analysis was performed using paraffin-embedded tumor specimens from 24 patients suffering from oropharyngeal, hypopharyngeal and oral squamous cell carcinomas. We observed that cyclooxygenase-2 immunoreactivity, compared to that of cyclooxygenase-1, was significantly increased in peritumoral lymphocytic infiltrates as well as in tumor cells. The expression of cyclooxygenase-2 in both tumor specimens and the surrounding peritumoral lymphocytic infiltrates supports the hypothesis that cyclooxygenase may be one of several important links between chronic inflammation and carcinogenesis.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Squamous Cell - enzymology
- Carcinoma, Squamous Cell - pathology
- Cyclooxygenase 1 -
- Cyclooxygenase 2 -
- Female -
- Humans -
- Isoenzymes - metabolism
- Lymphocytes, Tumor-Infiltrating - enzymology
- Male -
- Membrane Proteins -
- Mouth Neoplasms - enzymology
- Mouth Neoplasms - pathology
- Pharyngeal Neoplasms - enzymology
- Pharyngeal Neoplasms - pathology
- Prostaglandin-Endoperoxide Synthases - metabolism
- Find related publications in this database (Keywords)
- Cox-1
- Cox-2
- head and neck squamous cell carcinoma
- peritumoral lymphocytic infiltrate