Medizinische Universität Graz - Research portal
Selected Publication:
Thurnher, D; Kornfehl, J; Burian, M; Gedlicka, C; Selzer, E; Quint, C; Neuchrist, C; Kornek, GV.
Ifosfamide and mitoxantrone in the treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck.
Anticancer Drugs. 2001; 12(3):205-208
Doi: 10.1097/00001813-200103000-00005
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Thurnher Dietmar
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- A phase II study was performed to assess the safety and efficacy of ifosfamide and mitoxantrone in recurrent and/or metastatic squamous cell carcinomas of the head and neck. Treatment consisted of ifosfamide 1500 mg/m2 in 1000 ml saline, infused over 60 min and mesna 20% of the total dose of ifosfamide in three doses for 3 days combined with mitoxantrone 12 mg/m2 given as a short infusion on day 1. Treatment courses were repeated every 4 weeks until a total of six cycles. Twenty-two patients entered this trial, 13 of whom had received chemo- and radiation therapy, and nine patients who underwent radiation therapy with or without prior surgery. We observed no objective response, with the exception of two patients who experienced minor response (reduction of tumor size of 25%). The dose-limiting toxicity was myelosuppression with grade 3/4 leukocytopenia in seven patients (32%) and grade 3/4 neutropenia in 15 (68%). Severe organ toxicity except alopecia (91%) was not observed. Ifosfamide combined with mitoxantrone does not improve the therapeutic armentarium in recurrent squamous cell carcinoma of the head and neck.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Anemia - chemically induced
- Antigens, Neoplasm -
- Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Carcinoma, Squamous Cell - drug therapy
- DNA Topoisomerases, Type II -
- DNA-Binding Proteins -
- Diarrhea - chemically induced
- Female -
- Follow-Up Studies -
- Head and Neck Neoplasms - drug therapy
- Humans -
- Ifosfamide - administration & dosage Ifosfamide - adverse effects
- Isoenzymes - antagonists & inhibitors
- Male -
- Middle Aged -
- Mitoxantrone - administration & dosage Mitoxantrone - adverse effects
- Nausea - chemically induced
- Neoplasm Metastasis -
- Neoplasm Recurrence, Local -
- Neutropenia - chemically induced
- Stomatitis - chemically induced
- Topoisomerase II Inhibitors -
- Treatment Outcome -
- Vomiting - chemically induced
- Find related publications in this database (Keywords)
- head and neck cancer
- ifosfamide
- mitoxantrone
- palliative chemotherapy