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Lamm, W; Vormittag, L; Turhani, D; Erovic, BM; Czembirek, C; Eder-Czembirek, C; Thurnher, D.
The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines.
Head Neck. 2005; 27(12):1068-1072 Doi: 10.1002/hed.20285
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Leading authors Med Uni Graz: Thurnher Dietmar
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Abstract:: The protooncogenes Ets-1 and Ets-2 are involved in carcinogenesis of different tumors. Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor, has antiproliferative effects on tumor cells. The question arises whether nimesulide influences Ets-1 and Ets-2 synthesis in head and neck tumors. Expression of Ets-1 and Ets-2 was analyzed in tumor tissues by immunohistochemistry. The influence of nimesulide and an extracellular signal-regulated kinase (ERK) inhibitor on cell proliferation of two head and neck cancer cell lines and Ets-1 and Ets-2 expression was determined by automated cell counting and Western blotting, respectively. Immunohistochemistry showed a high expression of Ets-1 and Ets-2 in tumor tissues. In both cell lines, Ets-1 and Ets-2 expression were reduced after 24 and 48 hours by nimesulide. Both Ets-1 and Ets-2 are overexpressed in head and neck cancer specimens. Inhibition of Ets-1 and Ets-2 expression in head and neck cancer cell lines by nimesulide might explain the proapoptotic property of this COX-2 inhibitor. (c) 2005 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing): Blotting, Western -; Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell Line, Tumor -; Cell Proliferation - drug effects; Cyclooxygenase Inhibitors - pharmacology; Down-Regulation -; Flavonoids - pharmacology; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Humans -; Immunohistochemistry -; Proto-Oncogene Protein c-ets-1 - drug effects; Proto-Oncogene Protein c-ets-1 - metabolism; Proto-Oncogene Protein c-ets-2 - drug effects; Proto-Oncogene Protein c-ets-2 - metabolism; Sulfonamides - pharmacology
Find related publications in this database (Keywords): Ets-1; Ets-2; selective COX-2 inhibitor; head and neck cancer