Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pelzmann, M; Thurnher, D; Gedlicka, C; Martinek, H; Knerer, B.
Nimesulide and indomethacin induce apoptosis in head and neck cancer cells.
J Oral Pathol Med. 2004; 33(10):607-613
Doi: 10.1111/j.1600-0714.2004.00216.x
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are known to inhibit the enzyme cyclooxygenase (COX). There are two isoforms of the enzyme. Recent investigations indicate that both isoforms, COX-1 and COX-2, are involved in carcinogenesis. We investigated the effects of nimesulide, a COX-2 selective and indomethacin, a non-selective NSAID on the head and neck squamous cell carcinoma (HNSCC) cell lines SCC-9 and SCC-25. Effects on cell numbers and apoptosis were assayed by cell counting, immunofluorescence and fluorescence activated cell sorting (FACS). COX expression was examined by Western blotting. The investigated cell lines express COX-1 and COX-2. Nimesulide and indomethacin induce apoptosis and cause a reduction of cell number. Incubation with NSAIDs upregulated COX-2 expression. The results of our study on HNSCC cells together with data from different studies showing anti-cancer activity of NSAIDs suggest that COX inhibitors could play a role in HNSCC treatment and prevention.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Inflammatory Agents, Non-Steroidal - pharmacology
- Apoptosis - drug effects
- Blotting, Western -
- Carcinoma, Squamous Cell - enzymology
- Cell Proliferation - drug effects
- Cyclooxygenase 1 -
- Cyclooxygenase 2 -
- Cyclooxygenase 2 Inhibitors -
- Cyclooxygenase Inhibitors - pharmacology
- Flow Cytometry -
- Fluorescent Antibody Technique, Indirect -
- Head and Neck Neoplasms - enzymology
- Humans -
- Indomethacin - pharmacology
- Isoenzymes - antagonists & inhibitors
- Isoenzymes - biosynthesis
- Membrane Proteins -
- Prostaglandin-Endoperoxide Synthases - biosynthesis
- Sulfonamides - pharmacology
- Tumor Cells, Cultured -
- Find related publications in this database (Keywords)
- apoptosis
- cyclooxygenase
- head and neck cancer
- indomethacin
- nimesulide