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Thurnher, D; Bakroeva, M; Formanek, M; Knerer, B; Kornfehl, J.
Non-steroidal anti-inflammatory drugs inhibit telomerase activity in head and neck squamous carcinoma cell lines.
Head Neck. 2001; 23(12):1049-1055 Doi: 10.1002/hed.1150
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Leading authors Med Uni Graz: Thurnher Dietmar
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Abstract:: Antiproliferative effects in neoplastic cells of different origin have been attributed to non-steroidal anti-inflammatory Drugs (NSAIDs) during the past few decades. We tested the influence of NSAIDs and hydrocortisone on cell lines derived from head and neck squamous cell cancer (HNSCC) and on normal oral mucosal keratinocytes. Cell numbers were assayed by cell counting, proliferation, telomerase activity with a colorimetric assay, and cell cycle distribution by flow cytometry. In the neoplastic cell lines indomethacin and ibuprofen caused a dose-dependent reduction of cell numbers and telomerase activity without altering cell viability and increased the percentage of cells in G0/G1 phase. In normal oral mucosal keratinocytes, only minor effects could be detected in response to NSAIDs and hydrocortisone. These results demonstrate that NSAIDs have activity against HNSCC cells in vitro and may have clinical applications in combination with other therapeutic regimens. Copyright 2001 John Wiley & Sons, Inc.
Find related publications in this database (using NLM MeSH Indexing): Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Antineoplastic Agents - pharmacology; Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology; Cell Cycle - drug effects; Cell Division - drug effects; Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - pathology; Humans -; Hydrocortisone - pharmacology; Ibuprofen - pharmacology; Indomethacin - pharmacology; Keratinocytes -; Telomerase - antagonists & inhibitors; Tumor Cells, Cultured -
Find related publications in this database (Keywords): NSAID; telomerase; cell proliferation; head and neck cancer