Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ulrich-Pur, H; Erovic, BM; Soleiman, A; Jech, B; Pennwieser, W; Czembirek, C; Zielinski, CC; Thurnher, D.
Changes in Mcl-1 expression in rectal cancer in relation to neo-adjuvant radiotherapy.
Wien Klin Wochenschr. 2005; 117(4):136-140
Doi: 10.1007/s00508-004-0278-7
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Thurnher Dietmar
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Expression of the antiapoptotic protein myeloid cell leukemia-1 (Mcl-1) may be disordered in malignancies of the rectum. High levels of Mcl-1 may correlate with unfavourable clinical outcome. The aim of the study was to determine the biologic significance and the prognostic value of the protein Mcl-1 in a group of patients with rectal cancer using immunohistochemical staining in archival specimens. Expression of the Bcl-2 family member Mcl-1 was determined in 23 rectal malignancies. Half of the patients with rectal cancer were treated with preoperative short-term radiation therapy of 25 Gy followed by radical surgery; the other patients were treated just with radical surgery. Differences in Mcl-1 expression between irradiated and non-irradiated rectal cancer cells were analysed immunohistochemically, and Mcl-1 expression was correlated with overall survival. Induction of Mcl-1 expression by irradiation versus control in colorectal cancer cells was detected using Western blot. Mcl-1 was expressed at high levels in 35% of all specimens. Significantly stronger expression was detected in specimens of irradiated rectal cancer compared with non-irradiated tissues (p-value: 0.005). No association was seen between marker expression patterns and clinicopathological data of the respective patients. Our findings indicate that irradiated rectal cancer produces significantly higher levels of the antiapoptotic protein Mcl-1 than non-irradiated rectal carcinoma. The data also suggest that the high level of Mcl-1 was induced by the radiotherapy. As Mcl-1 is an antiapoptotic regulator, its over-expression in irradiated rectal cancer could constitute a detrimental development antagonizing the potential benefit of adjuvant radiotherapy. Further evaluation of the correlation between Mcl-1 expression and overall survival seems warranted.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - metabolism
- Adenocarcinoma - radiotherapy
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - metabolism
- Cell Line, Tumor -
- Colorectal Neoplasms - metabolism
- Colorectal Neoplasms - radiotherapy
- Female -
- Gene Expression Regulation, Neoplastic - radiation effects
- Humans -
- Male -
- Middle Aged -
- Myeloid Cell Leukemia Sequence 1 Protein -
- Neoadjuvant Therapy -
- Neoplasm Proteins - metabolism
- Prognosis -
- Proto-Oncogene Proteins c-bcl-2 - metabolism
- Radiotherapy, Adjuvant -
- Retrospective Studies -
- Statistics as Topic -
- Find related publications in this database (Keywords)
- Mcl-1
- apoptosis
- rectal adenocarcinoma
- irradiation