Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brunner, M; Erovic, B; Heiduschka, G; Schneider, S; Pammer, J; Frantal, S; Thurnher, D.
RCAS-1 serum and tumor levels in head and neck squamous cell carcinoma.
Eur Surg Res. 2010; 44(3-4):214-219
Doi: 10.1159/000314613
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- RCAS-1 is a transmembrane protein that is involved in the evasion of host immune surveillance by tumor cells. It has been found to be a valuable prognostic and diagnostic marker in a number of different malignancies. The objective of the study was to analyze the potency of RCAS-1 as a biomarker in the serum of patients with head and neck squamous cell carcinoma (HNSCC). ELISA was performed with prospectively collected serum samples from 60 patients with HNSCC (taken at the time of diagnosis, after 3 and 12 months) and from 31 healthy controls. To correlate serum levels with RCAS-1 expression in the tumor, immunohistochemical staining of RCAS-1 was done using a tissue microarray. Surprisingly, median sRCAS-1 levels were basically identical between tumor patients and controls. Interestingly, patients with low RCAS-1 values at the time of diagnosis had better disease-free survival. 62% of tumor samples expressed RCAS-1 but we could not demonstrate a correlation between protein expression and serum levels. This study was the first to correlate RCAS-1 levels in the serum and in the tumor of the same patients. RCAS-1 seems to have prognostic properties although larger studies will be necessary to fully evaluate its role in HNSCC. (c) 2010 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antigens, Neoplasm - blood Antigens, Neoplasm - metabolism
- Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - therapy
- Case-Control Studies -
- Disease-Free Survival -
- Female -
- Head and Neck Neoplasms - blood Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - therapy
- Humans -
- Immunohistochemistry -
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- Prognosis -
- Prospective Studies -
- Tumor Markers, Biological - blood Tumor Markers, Biological - metabolism
- Find related publications in this database (Keywords)
- Head and neck cancer
- RCAS-1
- Disease-free survival
- ELISA