Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Erovic, BM; Woegerbauer, M; Pammer, J; Selzer, E; Grasl, MCh; Thurnher, D.
Strong evidence for up-regulation of cyclooxygenase-1 in head and neck cancer.
Eur J Clin Invest. 2008; 38(1):61-66
Doi: 10.1111/j.1365-2362.2007.01896.x
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- Cyclooxygenase-1, in contrast to cyclooxygenase-2, is generally reported to be constitutively expressed as a housekeeping enzyme in many different tissues. A number of recently published reports, however, challenge the notion that cyclooxygenase-1 expression is invariably constitutive by demonstrating that this enzyme might be up-regulated under certain pathological conditions in, for example, breast or ovarian cancer cells. In this study we investigated the expression of cyclooxygenase-1 in head and neck tumours and compared it to the cyclooxygenase-1 expression levels in normal oropharyngeal epithelial cells. Paraffin-embedded pretreatment biopsies were obtained from head and neck tumour patients (n = 35). In addition, samples of normal oropharyngeal mucosa were taken from patients (n = 12) undergoing routine tonsillectomy. Cyclooxygenase-1 expression levels were determined by immunohistochemistry, Western blotting and real-time RT-PCR in cancerous tissue versus normal mucosa. Immunohistochemistry revealed overexpression of cyclooxygenase-1 in tumour biopsies compared to normal mucosa. Cyclooxygenase-1 was highly synthesized in the cytoplasm of neoplastic cells while significantly lower levels were detectable in normal mucosal cells. Western blotting and real-time RT-PCR also demonstrated higher cyclooxygenase-1 levels in tumour specimens compared to normal tissue samples. In this study we show for the first time that cyclooxygenase-1 is overexpressed in head and neck cancer cells compared to epithelial cells of normal mucosa.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Blotting, Western -
- Carcinoma, Squamous Cell - enzymology
- Cyclooxygenase 1 - metabolism
- Epithelial Cells - enzymology
- Female -
- Head and Neck Neoplasms - enzymology
- Humans -
- Male -
- Middle Aged -
- Oropharynx - enzymology
- Up-Regulation -
- Find related publications in this database (Keywords)
- COX-1
- head and neck cancer
- overexpression