Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Brunner, M; Thurnher, D; Heiduschka, G; Grasl, MCh; Brostjan, C; Erovic, BM.
Elevated levels of circulating endothelial progenitor cells in head and neck cancer patients.
J Surg Oncol. 2008; 98(7):545-550
Doi: 10.1002/jso.21139
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Brunner Markus
- Co-authors Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- Measurement of circulating endothelial cells (CECs) and progenitor cells (EPCs) has potential as a surrogate marker for monitoring anticancer treatment. This study evaluated the significance of CECs and EPCs in the blood of patients with head and neck squamous cell carcinoma. In a prospective trial fresh blood samples from 22 tumor patients and 18 controls were tested using multiparametric flow-cytometry. CECs were defined as CD31(+)/CD146(+) and CD45(-)/7AAD(-). EPCs were defined as CD133(+)/KDR(+) and CD3(-)/CD19(-)/CD33(-)/7AAD(-). Median levels (min/max) of CECs in the tumor group were 2 (0/5) at the time of diagnosis, 1 (0/5) 1 year after therapy and 2 (0/6) in the control cohort. Median levels of EPCs were 5 (1/41) before and 10 (0/21) after treatment in the tumor group compared to 2 (0/7) in the control cohort (P < 0.001 and P = 0.03). CEC and EPC levels showed no apparent correlation with tumor size and response to radiotherapy after 18 months of observation. In this pilot study CD133(+)/KDR(+) EPCs were significantly elevated in head and neck tumor patients before and after therapy. Our results warrant further studies on the use of EPCs as a surrogate marker for anticancer therapies in these patients. (c) 2008 Wiley-Liss, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antigens - metabolism
- Biomarkers, Tumor - blood
- Carcinoma, Squamous Cell - blood
- Carcinoma, Squamous Cell - mortality
- Carcinoma, Squamous Cell - therapy
- Case-Control Studies -
- Endothelial Cells - metabolism
- Female -
- Flow Cytometry -
- Head and Neck Neoplasms - blood
- Head and Neck Neoplasms - mortality
- Head and Neck Neoplasms - therapy
- Humans -
- Male -
- Middle Aged -
- Pilot Projects -
- Prospective Studies -
- Stem Cells - metabolism
- Vascular Endothelial Growth Factor Receptor-2 - metabolism
- Find related publications in this database (Keywords)
- HNSCC
- endothelial progenitor cells
- neovascularisation