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SHR Neuro Cancer Cardio Lipid Metab Microb

Kotowski, U; Heiduschka, G; Brunner, M; Czembirek, C; Eder-Czembirek, C; Schmidt, R; Fahim, T; Thurnher, D.
Radiosensitization of head and neck cancer cells by the phytochemical agent sulforaphane.
Strahlenther Onkol. 2011; 187(9):575-580 Doi: 10.1007/s00066-011-2218-6
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Leading authors Med Uni Graz: Thurnher Dietmar
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Abstract:: Sulforaphane is a naturally occurring compound found in broccoli and other cruciferous vegetables. Recently it gained attention because of its antiproliferative properties in many cancer cell lines. The aim of this study was to investigate whether sulforaphane could act as a radiosensitizer in head and neck squamous cell carcinoma cell lines. Four head and neck squamous cell carcinoma cell lines (i.e., (HNSCC) SCC9, SCC25, CAL27, and FADU) were treated with sulforaphane and subsequently irradiated. Then proliferation and clonogenic assays were performed. Apoptosis was detected by flow cytometry. Possible regulation of Akt and Mcl-1 was investigated by western blotting. Sulforaphane and radiation in combination leads to stronger inhibition of cell proliferation and of clonogenic survival than each treatment method alone. Western blot analysis of Akt and Mcl-1 showed no changed expression. Sulforaphane is a promising agent in the treatment of head and neck cancer due to its antiproliferative and radio-sensitizing properties. A combination of sulforaphane and radiation decreases clonogenic survival. Apoptosis is not regulated through Akt or the Mcl-1 protein.
Find related publications in this database (using NLM MeSH Indexing): Anticarcinogenic Agents - pharmacology; Apoptosis - drug effects; Apoptosis - radiation effects; Blotting, Western -; Carcinoma, Squamous Cell - pathology; Cell Division - drug effects; Cell Division - radiation effects; Cell Line, Tumor -; Head and Neck Neoplasms - pathology; Humans -; Isothiocyanates -; Myeloid Cell Leukemia Sequence 1 Protein -; Phytotherapy -; Proto-Oncogene Proteins c-akt - analysis; Proto-Oncogene Proteins c-bcl-2 - analysis; Radiation-Sensitizing Agents - pharmacology; Thiocyanates - pharmacology; Tumor Stem Cell Assay -
Find related publications in this database (Keywords): Sulforaphane; Radiation; Radiosensitizer; Head and neck cancer